Umami taste tested as a tool to curb overeating

NCT ID NCT07438028

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Approved
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First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding umami (the savory taste from MSG) to meals can help people eat fewer calories over two weeks. Researchers will compare three diets: regular food, regular food with added umami, and lower-calorie food with added umami. Thirty healthy adults will try each diet for two weeks, and their daily calorie intake will be measured.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Monosodium glutamate (MSG)
What this could lead to
If successful, this could show that adding umami to meals helps people eat fewer calories without losing satisfaction, pointing toward healthier eating strategies.
What could go wrong
This is a small, early-stage study in healthy adults, so results may not apply to the general population. The effect on long-term weight management is unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy: as judged by the participant; * Age 16-65 years at the time of inclusion, assessed by date of birth; * Proper understanding of the Dutch language, as questionnaires will be in Dutch; * Able to visit Wageningen University, as required for dietary intervention and testing; * Body mass index 20-30 kg/m2; * Having normal taste ability, assessed using Mueller taste strip test, ≥12 out of 20 assessed correctly. Exclusion Criteria: * Suffering from endocrine- or gastro-intestinal diseases or other diseases that might influence study outcomes (such as diabetes, Crohn's disease, cardiovascular disease, hypertension, etc.); * Diagnosed with eating disorders (currently or in the past); * Diagnosed with taste or smell disorders in the past six months; * Pregnant or lactating during the study intervention; * Following a strict dietary regime; * Extreme physical activity (\>10 hours per week moderate/high intensity exercise); * Gain or loss of more than 5 kgs in the last six months prior to study entry; * Suffering from lack of appetite for any reason; * Use of medication that may influence the appetite (medication will be judged by the medical investigator); * Having a food allergy and/or intolerance for foods used in the dietary intervention (e.g. lactose intolerance, gluten intolerance, MSG sensitivity). This will be assessed with an open question; * Consumes more than 14 (women) or 21 (men) glasses of alcohol per week; * Consumes MSG-rich sauces (soy sauce, ketjap and/or curry paste) more than once per day, or consumes more than 3 savoury food items (paprika chips, instant noodles, sundried tomatoes and/or pre-packaged seasonings) per day. This will be assessed with a frequency of consumption table; * Irregular eating pattern. This will be measured with a frequency of meal/food consumption table, and is defined as: frequency of breakfast consumption less than once per week; * Unwilling to maintain regular exercise pattern during the study period. This will be assessed with a yes/no question; * Unwilling to quit use of soft or hard drugs during the intervention; * Student or personnel of the division of Human Nutrition and Health, Wageningen University; * Participating in any other intervention study/studies or planning to participate in another intervention study during the study period.

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As listed by the trial registrant

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How to take part

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Contacts and locations

Locations

  • Department of Human Nutrition, Wageningen University

    Wageningen, Gelderland, 6708WE, Netherlands

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