Ultrasound test may spot liver trouble early in transplant patients

NCT ID NCT03865589

Completed Diagnosis Sponsor: Children's Mercy Hospital Kansas City Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This study is testing whether a special ultrasound technique, called shear wave elastography, can predict a serious liver complication called sinusoidal obstruction syndrome (SOS) in children and adults receiving bone marrow or stem cell transplants. Researchers will measure liver stiffness with ultrasound before and after transplant to see if changes can identify patients at risk. The goal is to improve early detection and help doctors tailor treatment more quickly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ultrasound shear wave elastography
What this could lead to: If successful, this could provide a non-invasive way to predict liver damage early after transplant, helping doctors intervene sooner.
What could go wrong: This is an observational diagnostic study, not a treatment trial. The test may not be accurate enough to change outcomes, and results may not apply to all transplant patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE MARROW TRANSPLANT COMPLICATIONS SINUSOIDAL OBSTRUCTION SYNDROME STEM CELL TRANSPLANT COMPLICATIONS VENO OCCLUSIVE DISEASE, HEPATIC

Contacts and locations

Locations

Children's Mercy

Kansas City, Missouri, 64108, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University

Durham, North Carolina, 27705, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of California, San Francisco

San Francisco, California, 94143, United States

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