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Radiation boost may help CAR-T cells wipe out stubborn lymphoma

NCT ID NCT05514327

Recruiting now Disease control Sponsor: Peking Union Medical College Hospital Source: ClinicalTrials.gov ↗

First seen Mar 28, 2026 · Last updated Jun 17, 2026 · Updated 15 times

Summary

This study tests whether giving a special type of radiation (ultra-fraction radiotherapy) before CAR-T cell therapy can safely and effectively treat adults with relapsed or refractory diffuse large B-cell lymphoma. About 20 participants who have not responded to at least two prior treatments will receive the radiation followed by CAR-T cells. The main goal is to see how many patients achieve remission at 3 months.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Peking Union Medical College Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100730, China

    Contact Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRIDGING THERAPY CAR-T CAR-T DIFFUSE LARGE B-CELL LYMPHOMA RADIOTHERAPY