Cord blood CAR-T: a new hope for adults with B-Cell leukemia?

NCT ID NCT07256353

Not yet recruiting Disease control Sponsor: The General Hospital of Western Theater Command Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early-stage trial is testing a new treatment for adults with B-cell acute lymphoblastic leukemia (B-ALL) using immune cells from donated umbilical cord blood that are engineered to attack cancer cells (UCAR-T). The study will enroll 50 participants to check safety, find the best dose, and see if the treatment can clear leukemia from the bone marrow. Participants will receive the UCAR-T cells by IV and be closely monitored for side effects and response for up to a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: allogeneic umbilical cord blood-derived CAR-T cells (UCAR-T)
What this could lead to: If it works, this could provide a safer, more accessible treatment option for adults with B-cell acute lymphoblastic leukemia who have limited alternatives.
What could go wrong: This is a very early (Phase 1) trial with only 50 participants, so safety and effectiveness are not yet proven. There are risks of serious side effects like cytokine release syndrome or organ damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell acute lymphoblastic leukemia B-cell adult acute lymphocytic leukemia Burkitt lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA, ADULT

Contacts and locations

Locations

The General Hospital of Western Theater Command

Chengdu, Sichuan, China

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