Could a simple pill stop recurring UTIs? new trial seeks answers

NCT ID NCT07184827

Recruiting now Prevention Sponsor: TCM Biotech International Corp. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 3 trial tests whether the drug U101 (pentosan polysulfate sodium) can prevent recurrent urinary tract infections (UTIs) in women aged 20 to 75. About 348 women with a history of frequent UTIs will take either U101 or a placebo daily for 24 weeks. Researchers will track how many women stay infection-free and whether their quality of life improves.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pentosan polysulfate sodium (U101)
What this could lead to: If it works, this could provide a new daily pill to help women with frequent UTIs avoid repeat infections and improve quality of life.
What could go wrong: This is a phase 3 trial, but results are not yet known. The drug may not work better than placebo, and side effects are possible. It is only tested in women aged 20-75.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

urinary tract infection urinary tract infections, recurrent, susceptibility to

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT URINARY TRACT INFECTIONS IN WOMEN

Contacts and locations

Locations

Chang Gung Memorial Hospital, Kaohsiung Branch
RECRUITING

Kaohsiung City, Taiwan
Chang Gung Memorial Hospital, Linkuo Branch
RECRUITING

Taoyuan, Taiwan
Chang Gung Memorial Hospital, Taipei Branch
RECRUITING

Taipei, Taiwan
China Medical University Hospital
RECRUITING

Taichung, Taiwan
Chung Shan Medical University Hospital
RECRUITING

Taichung, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
ACTIVE_NOT_RECRUITING

Kaohsiung City, Taiwan
National Cheng Kung University Hospital
RECRUITING

Tainan, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, Taiwan
Taichung Veterans General Hospital
RECRUITING

Taichung, Taiwan
Taipei Medical University Hospital
RECRUITING

Taipei, Taiwan
Taipei Tzu Chi Hospital
RECRUITING

New Taipei City, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, Taiwan
Tri-Service General Hospital (TSGH)
RECRUITING

Taipei, Taiwan

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