New drug tuvusertib targets recurrent brain tumors in phase 2 trial

NCT ID NCT07417761

Recruiting now Disease control Sponsor: Grupo Español de Investigación en Neurooncología Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests the drug tuvusertib in 56 adults with recurrent IDH-mutant astrocytoma, a type of brain tumor. Participants take tuvusertib daily for two weeks, then one week off. The main goal is to see if the drug can improve the number of patients whose cancer does not worsen after six months. The study includes two groups: those who cannot have surgery and those who can.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tuvusertib
What this could lead to: If successful, this could provide a new treatment option for people with recurrent IDH-mutant astrocytoma, potentially slowing tumor growth.
What could go wrong: This is a small, early-phase trial with only 56 participants. The drug may not work as hoped, and side effects are possible. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ASTROCYTOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

astrocytoma (excluding glioblastoma)

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTROCYTOMA

Contacts and locations

Locations

Hospital Clinic de Barcelona
RECRUITING

Barcelona, Barcelona, 08036, Spain
Hospital Clínico Universitario de Salamanca
NOT_YET_RECRUITING

Salamanca, Salamanca, 37007, Spain
Hospital Clínico Universitario de Valencia - INCLIVA
RECRUITING

Valencia, Valencia, 46010, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, Madrid, 28034, Spain
Hospital Universitario Son Espases
RECRUITING

Palma de Mallorca, Balearic Islands, 07120, Spain
Hospital Universitario Vall d'Hebron
RECRUITING

Barcelona, Barcelona, 08035, Spain
Hospital Universitario Virgen de las Nieves
RECRUITING

Granada, Granada, 18014, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, Sevilla, 41013, Spain
Hospital Universitario de Cruces
RECRUITING

Barakaldo, Bizkaia, 48903, Spain
Hospital Álvaro Cunqueiro
RECRUITING

Vigo, Pontevedra, 36312, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.