New hope for arthritis sufferers? drug tulisokibart put to the test

NCT ID NCT07176390

Ongoing Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called tulisokibart for people with active rheumatoid arthritis who are already taking methotrexate. About 182 participants will receive either tulisokibart or a placebo to see if the drug reduces joint pain and swelling better than a dummy treatment. The main goal is to check if at least 20% improvement in symptoms is achieved after 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tulisokibart
What this could lead to: If it works, this could point toward a new treatment option for people with rheumatoid arthritis whose symptoms aren't well controlled by methotrexate alone.
What could go wrong: This is a mid-stage trial with only 182 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHRITIS, RHEUMATOID

Contacts and locations

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Locations

AA Medical Research Center ( Site 1027)

Grand Blanc, Michigan, 48439, United States
AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Mesa ( Site 1033)

Mesa, Arizona, 85210, United States
AARA Clinical Research - Murfreesboro Medical Clinic ( Site 1034)

Murfreesboro, Tennessee, 37128, United States
Advanced Rheumatology of Houston - Woodlands ( Site 1000)

The Woodlands, Texas, 77382, United States
Arizona Arthritis & Rheumatology Associates, P.C. ( Site 1018)

Glendale, Arizona, 85306-9802, United States
Arthritis & Osteoporosis Medical Center - La Palma ( Site 1024)

La Palma, California, 90623, United States
Barnet Hospital ( Site 2102)

London, EN5 3DJ, United Kingdom
CECIM ( Site 1208)

Santiago, Region M. de Santiago, 8320000, Chile
CIREEM SAS ( Site 1304)

Bogota, Cundinamarca, 110111, Colombia
CIUSSS de l'Estrie - CHUS, Hotel-Dieu de Sherbrooke ( Site 1106)

Sherbrooke, Quebec, J1G 2E8, Canada
Centre de Recherche Musculo-Squelettique ( Site 1101)

Trois-Rivières, Quebec, G9A 3X2, Canada
Centro de Estudios GyC ( Site 1206)

Santiago, Region M. de Santiago, 7500504, Chile
Chapel Allerton Hospital ( Site 2106)

Leeds, LS7 4SA, United Kingdom
Chungnam national university hospital ( Site 2303)

Daejeon, Taejon-Kwangyokshi, 35015, South Korea
Clinica Dermacross ( Site 1203)

Santiago, Region M. de Santiago, 7640881, Chile
Clinica de la Costa S.A.S. ( Site 1301)

Barranquilla, Atlántico, 080020, Colombia
Epic Medical Research ( Site 1004)

Red Oak, Texas, 75154, United States
Fundación Valle del Lili ( Site 1305)

Cali, Valle del Cauca Department, 760032, Colombia
Greater Chicago Specialty Physicians - Orland Park ( Site 1043)

Orland Park, Illinois, 60467, United States
HMD Research LLC ( Site 1016)

Orlando, Florida, 32819, United States
HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg G ( Site 1602)

Hamburg, 20095, Germany
Hanyang University Seoul Hospital ( Site 2300)

Seoul, 04763, South Korea
Hirose Clinic ( Site 2601)

Tokorozawa, Saitama, 359-1111, Japan
Hospital Clinico Universitario de Santiago ( Site 1903)

Santiago de Compostela, La Coruna, 15706, Spain
Hospital Universitari Parc Tauli ( Site 1900)

Sabadell, Barcelona, 8208, Spain
Hospital Universitari Vall d'Hebron ( Site 1901)

Barcelona, 08035, Spain
Hospital Universitario Marqués de Valdecilla ( Site 1906)

Santander, Cantabria, 39008, Spain
Kai Clinic ( Site 2600)

Miyazaki, 880-0053, Japan
Kansas City Physician Partners ( Site 1032)

Kansas City, Missouri, 64111, United States
Linfen Central Hospital ( Site 2507)

Linfen, Shanxi, 041000, China
MICS Centrum Medyczne Bydgoszcz ( Site 1807)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-065, Poland
MICS Centrum Medyczne Torun ( Site 1803)

Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
MICS Centrum Medyczne Warszawa ( Site 1805)

Warsaw, Masovian Voivodeship, 00-874, Poland
Medicover München Ost MVZ ( Site 1607)

München, Bavaria, 81667, Germany
Mount Sinai Hospital ( Site 1102)

Toronto, Ontario, M5T 3L9, Canada
NZOZ BIF-MED ( Site 1802)

Bytom, Silesian Voivodeship, 41-902, Poland
Nagaoka Red Cross Hospital ( Site 2604)

Nagaoka, Niigata, 940-2085, Japan
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji ( Site 1806)

Warsaw, Masovian Voivodeship, 02-637, Poland
PEOPLE'S HOSPITAL OF XINJIANG UYGUR AUTONOMOUS REGION ( Site 2515)

Ürümqi, Xinjiang, 830001, China
Peking University First Hospital ( Site 2511)

Beijing, Beijing Municipality, 100034, China
Physician Research Collaboration, LLC ( Site 1002)

Lincoln, Nebraska, 68516, United States
Pingxiang People's Hospital ( Site 2512)

Pingxiang, Jiangxi, 337000, China
Pontificia Universidad Catolica de Chile-CICUC ( Site 1209)

Santiago, Region M. de Santiago, 8330073, Chile
Rheuma-Research Lausitz ( Site 1604)

Cottbus, Brandenburg, 03042, Germany
Rheumatologische Schwerpunktpraxis ( Site 1603)

Berlin, 12161, Germany
Rheumatology Associates ( Site 1026)

Arlington, Texas, 76012, United States
Rheumatology Specialty Center ( Site 1030)

Willow Grove, Pennsylvania, 19090, United States
Rheumazentrum Ratingen Studienambulanz ( Site 1601)

Ratingen, North Rhine-Westphalia, 40878, Germany
Sasebo Chuo Hospital ( Site 2602)

Sasebo, Nagasaki, 857-1195, Japan
Soon Chun Hyang University Cheonan Hospital ( Site 2304)

Cheonan-si, Chungcheongnam-do, 31151, South Korea
Sweet Hope Research Specialty, Inc ( Site 1015)

Hialeah, Florida, 33016, United States
Szpital Uniwersytecki nr 2 im. Dr. Jana Biziela-Klnk Reumatologii i Ukladowych Chorob Tkanki Lacznej ( Site 1804)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland
Taizhou Hospital of Zhejiang Province ( Site 2506)

Linhai, Zhejiang, 317000, China
Tekton Research, LLC. ( Site 1008)

Fort Collins, Colorado, 80528, United States
The First Affiliated Hospital of Xiamen University. ( Site 2510)

Xiamen, Fujian, 361003, China
The Princess Alexandra Hospital NHS Trust ( Site 2103)

Harlow, England, CM20 1QX, United Kingdom
The Third Affiliated Hospital, Sun Yat-sen University ( Site 2514)

Guangzhou, Guangdong, 510630, China
Toshin Yoshida Internal Medicine Rheumatology ( Site 2606)

Hanishina-gun, Nagano, 389-0606, Japan
University of Yamanashi Hospital ( Site 2603)

Chūō, Yamanashi, 409-3898, Japan
Xinxiang Central Hospital ( Site 2501)

Xinxiang, Henan, 453000, China
Zespół Poradni Specjalistycznych Reumed Filia nr 1 Wallenroda ( Site 1801)

Lublin, Lublin Voivodeship, 20-607, Poland
altoona center for clinical research ( Site 1005)

Duncansville, Pennsylvania, 16635, United States

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