Could removing tubes first, ovaries later prevent ovarian cancer just as well?

NCT ID NCT04294927

Recruiting now Prevention Sponsor: University Medical Center Nijmegen Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for women with BRCA1, BRCA2, or other gene mutations that greatly raise ovarian cancer risk. Instead of removing both ovaries and fallopian tubes at once, researchers are testing whether removing just the tubes first and delaying ovary removal is equally safe. The goal is to see if this two-step approach prevents cancer while avoiding early menopause. About 3,000 women will take part across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could offer a safer, less invasive option for women with high genetic risk of ovarian cancer, preserving ovarian function longer.
What could go wrong: This is a large but non-randomized study; results may take years. There is a risk that delaying ovary removal could allow cancer to develop in the ovaries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRCA1 GENE MUTATION BRCA2 GENE MUTATION BRIP1 GENE MUTATION OVARIAN CANCER RAD51C GENE MUTATION RAD51D GENE MUTATION

Contacts and locations

Locations

AC Camargo Cancer Centre
RECRUITING

São Paulo, Brazil
Akershus University Hospital
ACTIVE_NOT_RECRUITING

Nordbyhagen, Norway
Amphia
RECRUITING

Breda, Netherlands
Amsterdam University Medical Center
RECRUITING

Amsterdam, Netherlands
Antoni van Leeuwenhoek
RECRUITING

Amsterdam, Netherlands
Bonifraterskie Centrum Medyczne
RECRUITING

Katowice, Poland
Catharina Ziekenhuis
RECRUITING

Eindhoven, North Brabant, 5623 EJ, Netherlands
Chris O'Brien Lifehouse
RECRUITING

Sydney, New South Wales, 2050, Australia
Cork University Hospital
RECRUITING

Cork, Ireland
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke University Hospital
RECRUITING

Durham, North Carolina, 27705, United States
Elisabeth-TweeSteden Ziekenhuis
RECRUITING

Tilburg, North Brabant, Netherlands
Epworth Hospital
RECRUITING

Richmon, Victoria, 3121, Australia
Erasmus Medical Center
RECRUITING

Rotterdam, Netherlands
Evang. Kliniken Essen-Mitte
RECRUITING

Essen, Germany
Evangelische Waldkrankenhaus Spandau Berlin
RECRUITING

Berlin-Spandau, Germany
Frances Perry House
RECRUITING

Melbourne, Victoria, 3050, Australia
Gdynia Oncology Centre
RECRUITING

Gdynia, Poland
Gemelli Hospital
RECRUITING

Rome, Italy
Greenslopes Private Hospital
RECRUITING

Brisbane, Queensland, 4120, Australia
Harris Health Lyndon B. Johnson Hospital
RECRUITING

Houston, Texas, 77026, United States
Hopital Universitaire Bruxelles
RECRUITING

Brussels, Belgium
Hospital Británico
RECRUITING

Montevideo, Uruguay
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Humanitas San Pio X
RECRUITING

Milan, Italy
Instituto Nacional de Cancerología
RECRUITING

Mexico City, Mexico
Isala Klinieken
RECRUITING

Zwolle, Netherlands
Karolinksa Institutet
RECRUITING

Stockholm, Sweden
King Edward Memorial Hospital
RECRUITING

Perth, Western Australia, 6008, Australia
Klinikum Lippe Detmold
NOT_YET_RECRUITING

Detmold, Germany
Klinikum St. Marien Amberg
NOT_YET_RECRUITING

Amberg, Germany
Leiden University Medical Center
RECRUITING

Leiden, Netherlands
MD Anderson Cancer Centre
RECRUITING

Houston, Texas, 77030-4009, United States
Maastricht University Medical Center
RECRUITING

Maastricht, Limburg, Netherlands
Maxima Medical Center
RECRUITING

Veldhoven, Netherlands
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Medical Center Leeuwarden
RECRUITING

Leeuwarden, Netherlands
Medical University of Graz
RECRUITING

Graz, Austria
Medical University of Silesia
RECRUITING

Katowice, Poland
Medisch Spectrum Twente
RECRUITING

Enschede, Netherlands
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Mercy Hospital
RECRUITING

Melbourne, Victoria, 3084, Australia
Monash Health
RECRUITING

Melbourne, Australia
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
National Cancer Institute Warsaw
RECRUITING

Warsaw, Poland
Oslo University Hospital
RECRUITING

Oslo, Norway
Peter MacCallum Centre
RECRUITING

Melbourne, Australia
Radboudumc
RECRUITING

Nijmegen, Gelderland, Netherlands
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia
Royal Brisbane Hospital
RECRUITING

Brisbane, Queensland, 4006, Australia
Royal Womens Hospital
RECRUITING

Melbourne, Australia
San Gerardo Hospital
RECRUITING

Monza, Italy
St Andrew War Memorial Hospital
RECRUITING

Brisbane, Queensland, 4001, Australia
Stavanger Uniersity Hospital
RECRUITING

Stavanger, Norway
The Mater Hospital
RECRUITING

Brisbane, Australia
UChicago Medicine
RECRUITING

Chicago, Illinois, 60637, United States
Universita di Bologna
RECRUITING

Bologna, Italy
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, Belgium
University Medical Center Groningen
RECRUITING

Groningen, Netherlands
University Medical Center Utrecht
RECRUITING

Utrecht, Netherlands
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Vall D'Hebron Barcelona
RECRUITING

Barcelona, Spain
Vancouver General Hospital
RECRUITING

Vancouver, Canada
Washington University Medical Center
RECRUITING

St Louis, Missouri, 63110, United States
Western Health
RECRUITING

St Albans, Victoria, 3021, Australia
Westmead hospital
RECRUITING

Sydney, New South Wales, 2145, Australia

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