New drug cocktail aims to stop leukemia relapse after transplant
NCT ID NCT07562568
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding SHR2554 and azacitidine to standard chemotherapy before a stem cell transplant can lower the chance of cancer returning in people aged 15-60 with high-risk or relapsed leukemia or myelodysplastic syndromes. Half the participants will get the new drug combo, while the other half receives standard chemo. The main goal is to see if the combo reduces relapse rates over two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SHR2554 combined with azacitidine
- What this could lead to
- If successful, this combination could reduce the chance of leukemia or MDS returning after a stem cell transplant, improving long-term survival.
- What could go wrong
- This is an early phase 2 trial with only 160 participants, so results may not apply to everyone. The treatment involves strong chemotherapy and transplant, which carry serious risks like infection and graft-versus-host disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215006, China
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