Gut bacteria may unlock prostate cancer drug resistance

NCT ID NCT06616597

First seen Feb 19, 2026 · Last updated May 08, 2026 · Updated 15 times

Summary

This study tests whether adding dexamethasone or metronidazole (a gut bacteria-targeting antibiotic) can make abiraterone work again in men with metastatic prostate cancer whose disease has stopped responding to the drug. About 58 men will receive one of these combinations for up to 24 weeks. The main goal is to see if PSA levels drop by at least 30%.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    RECRUITING

    Baltimore, Maryland, 21231, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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