New smart drug targets HER2 lung cancer in Mid-Stage trial

NCT ID NCT06496490

Recruiting now Disease control Sponsor: Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing TQB2102, a drug that combines an antibody with chemotherapy to specifically attack lung cancer cells that have HER2 gene abnormalities. The study will enroll 270 adults with advanced non-small cell lung cancer that cannot be surgically removed. Researchers will measure how many patients' tumors shrink or disappear, and how long that effect lasts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TQB2102 (a targeted antibody-drug conjugate that delivers chemotherapy directly to cancer cells with HER2 abnormalities)
What this could lead to: If successful, this could provide a new treatment option for people with advanced lung cancer that has specific HER2 gene changes, potentially shrinking tumors and delaying disease progression.
What could go wrong: This is a mid-stage trial with only 270 participants, so results may not apply to everyone. The drug can cause side effects like any chemotherapy, and it may not work for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Affiliated Cancer Hospital of Shandong First Medical University
NOT_YET_RECRUITING

Jinan, Shandong, 250117, China
Beijing Cancer Hospital
NOT_YET_RECRUITING

Beijing, 100142, China
First Affiliated Hospital of Gannan Medical University
NOT_YET_RECRUITING

Ganzhou, Jiangxi, 341099, China
Foshan First People's Hospital
NOT_YET_RECRUITING

Foshan, Guangdong, 528000, China
Fudan University Shanghai Cancer Center
NOT_YET_RECRUITING

Shanghai, 200032, China
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, 350014, China
Guangxi Medical University Cancer Hospital
NOT_YET_RECRUITING

Nanning, Guangxi, 53000, China
Harbin Medical University cancer hospital
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150081, China
Henan Cancer Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, 450000, China
Hunan Provincial Tumor Hospital
NOT_YET_RECRUITING

Changsha, Hunan, 410031, China
Jiangmen Central Hospital
NOT_YET_RECRUITING

Jiangmen, Guangdong, 529000, China
Jiangsu Provincial People's Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210000, China
Jilin Cancer Hospital
NOT_YET_RECRUITING

Changchun, Jilin, 130012, China
Leshan People's Hospital
NOT_YET_RECRUITING

Leshan, Sichuan, 614099, China
Sichuan Cancer Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, 610040, China
Sichuan Provincial People's Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, 610000, China
Sun Yat-sen University Cancer Center
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510060, China
The 1th School of Medicine,School of Information and Engineering.The 1th Affiliated Hospital of WMU
NOT_YET_RECRUITING

Wenzhou, Zhejiang, 325015, China
The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Xi'an Jiaotong University
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710000, China
The Second Affiliated Hospital of Zunyi Medical University
NOT_YET_RECRUITING

Zunyi, Guizhou, 563006, China
The Second People's Hospital of Shenzhen
NOT_YET_RECRUITING

Shenzhen, Guangdong, 518035, China
Tianjin Medical University Cancer Institute&Hpspital
NOT_YET_RECRUITING

Tianjin, 300181, China
Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, Hubei, 430000, China
Xinjiang Uygur Autonomous Region Cancer Hospital
NOT_YET_RECRUITING

Ürümqi, Xinjiang, 830001, China

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