New drug duo aims to shrink enlarged spleens in myelofibrosis patients

NCT ID NCT06122831

Recruiting now Disease control Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether combining two experimental drugs (TQ05105 and TQB3617) can safely shrink the spleen and improve symptoms in people with intermediate- or high-risk myelofibrosis, a type of bone marrow cancer. About 92 adults will take the pills daily, and researchers will monitor spleen size and side effects. The goal is to control the disease, not cure it.

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Conditions

The condition(s) this trial relates to.

myelofibrosis primary myelofibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYELOFIBROSIS

Contacts and locations

Locations

Affiliated Hospital of Chengde Medical College
NOT_YET_RECRUITING

Chengde, Hebei, 067020, China
Cangzhou People's Hosipital
NOT_YET_RECRUITING

Cangzhou, Hebei, 061014, China
Central Hospital Of Minhang District, Shanghai
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200000, China
Guangdong Provincial People's Hospital
NOT_YET_RECRUITING

Guangzhou, Guangdong, 525000, China
Guangxi Zhuang Autonomous Region People's Hospital
NOT_YET_RECRUITING

Nanning, Guangxi, 530016, China
Henan Cancer Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, 450003, China
Heping Hospital Affiliated to Changzhi Medical College
NOT_YET_RECRUITING

Changzhi, Shanxi, 046000, China
North China of Science and Technology University Affiliated Hospital
NOT_YET_RECRUITING

Tangshan, Hebei, 063000, China
People's Hospital of Tianjin City
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300122, China
Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200000, China
Shanghai Sixth People's Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200233, China
Tai'an City Central Hospital
NOT_YET_RECRUITING

Tai’an, Shandong, 271099, China
The Affiliated Hospital of Inner Mongolia Medical University
NOT_YET_RECRUITING

Hohhot, Inner Mongolia, 010000, China
The First Affiliated Hospital of Xinjiang Medical University
NOT_YET_RECRUITING

Ürümqi, Xinjiang, 830011, China
The First Hospital of Harbin
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150010, China
The First Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130021, China
The Public Hospital of Wuxi
NOT_YET_RECRUITING

Wuxi, Jiangsu, 214000, China
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology
NOT_YET_RECRUITING

Wuhan, Hubei, 430071, China
Union Hospital Tongji College Huazhong Unizersity of Science And Technology
NOT_YET_RECRUITING

Wuhan, Hubei, 430071, China
Wuhan University Zhongnan Hospital
NOT_YET_RECRUITING

Wuhan, Hubei, 430071, China
Xi 'An Jiaotong University Second Affiliated Hospital
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710000, China
Xingtai People's Hospital
NOT_YET_RECRUITING

Xingtai, Hebei, 054031, China

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