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Light on the brain: different frequencies may fine-tune motor performance

NCT ID NCT07707284

Knowledge-focused Sponsor: Hospital de Clinicas de Porto Alegre Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 29, 2026 · Updated 3 times

Summary

This study explores whether shining near-infrared light on the scalp — a technique called transcranial photobiomodulation — can change how the brain controls movement. Twenty healthy adults aged 18 to 35 will receive light at different pulse frequencies (continuous, 10 Hz, 40 Hz, or 100 Hz) or a sham treatment in random order. Researchers will measure brain excitability using magnetic stimulation and fine motor skill with a smartphone finger-tapping test. The goal is to see if certain frequencies affect the brain more than others, independent of the total light dose.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial photobiomodulation (tPBM) using near-infrared light
What this could lead to
If successful, this could reveal optimal light frequencies for boosting brain function, potentially aiding future treatments for motor or cognitive disorders.
What could go wrong
This is a small, early-phase study in healthy volunteers, so results may not apply to people with medical conditions. The effects may be subtle or not clinically meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2027

An estimate. Start dates often move.

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Voluntary Participation: Participants who are clear of their cognitive faculties, capable of understanding all experimental procedures, and who provide written informed consent prior to enrollment. * Neurologically and Psychiatrically Healthy Status: Individuals with no current or prior history of neurological, neurodevelopmental, or psychiatric conditions; * Age Range: Young adult volunteers aged between 18 and 35 years. Exclusion Criteria: * Use of any continuous psychotropic medication within the past 12 months. * Any current psychiatric diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). * Diagnosis of any neurological disorder capable of altering cortical excitability (e.g., seizures/epilepsy, cerebrovascular accidents/stroke, brain tumors). * Any clinical, psychological, or social condition that, in the investigator's opinion, places the participant at an increased risk, compromises participant safety, or precludes full compliance and successful completion of the study protocol. * Presence of any intracranial devices or implants, including cochlear implants and aneurysm clips. * Severe or uncompensated systemic medical illness that could interfere with study participation or confound physiological outcomes. * Participation in any other interventional neuromodulation study within the preceding 6 months.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cortical excitability Healthy volunteers (HV) Transcranial photobiomodulation

How to take part

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  1. The places running it

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  2. The official record

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  3. A doctor treating you

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Contacts and locations

Locations

  • Hospital de Clínicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, Brazil

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