New hope for tough esophageal cancers: triple therapy shows promise
NCT ID NCT07272291
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is for people with esophageal cancer that did not shrink after initial treatment. It tests whether adding low-dose radiation to a combination of immunotherapy (toripalimab) and chemotherapy can improve outcomes. Participants will receive the treatment before surgery, and those who still have cancer after surgery will continue immunotherapy for up to a year. The goal is to see if this approach can reduce or eliminate the tumor before surgery.
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Conditions
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- Can an AI eye guide surgeons to safer, faster cancer removal?
- Can a triple punch of immunotherapy and chemoradiation wipe out esophageal tumors before surgery?
- Can early tumor response guide smarter cancer treatment?
- Could a smart combo of drugs and radiation help some esophageal cancer patients skip surgery?
- Could more surgery and radiation after immunotherapy keep esophageal cancer at bay?
- Blood and tissue markers could forecast esophageal cancer return