Could a dab of gel before the needle end dental injection pain?
NCT ID NCT07707557
First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time
Summary
This trial tests whether applying a 5% lidocaine gel to the gums before a standard numbing injection reduces pain during tooth extractions. About 120 adults will receive either the injection alone or the gel plus injection. Pain levels are measured using a simple 0-10 scale at several points after the procedure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 5% topical lidocaine gel applied before a lidocaine injection
- What this could lead to
- If effective, this simple step could make dental injections less painful for millions of patients.
- What could go wrong
- This is a small early-phase trial, so results may not apply to all dental procedures or patient groups.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
-
Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. patients aged 18-65 years of age who underwent extraction of tooth. 2. no intolerance or allergies to lidocaine 2% infiltration and lidocaine 5% topical. 3. Patients should not take sedative analgesics or anxiety medications in the 12 hour prior to extraction Exclusion Criteria: 1. Pregnant or lactating women. 2. Patient not giving consent to undergo the procedure. 3. Patient with occurrence of skin or mucosal allergy or abnormal reaction at the vascular access site.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Abbasi Shaheed Hospital and Karachi Medical and Dental College
Karachi, Sindh, 74200, Pakistan
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