New cancer drug targets specific genetic weakness in tumors
NCT ID NCT06810544
Summary
This study is testing a new oral drug called TNG456, both alone and combined with another cancer drug (abemaciclib), in people with advanced solid tumors that have a specific genetic change called MTAP loss. The main goals are to find safe doses and see if the treatment can shrink tumors in cancers like lung cancer, brain tumors, and others. About 191 participants who have tried standard treatments without success may join this early-phase trial.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dana Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Mayo Clinic Cancer Center
RECRUITINGRochester, Minnesota, 55905-0001, United States
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Mayo Clinic Jacksonville
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic Scottsdale
RECRUITINGScottsdale, Arizona, 85259-5452, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 11065, United States
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NEXT Virginia
RECRUITINGFairfax, Virginia, 22031, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Northwestern Memorial Hospital
RECRUITINGChicago, Illinois, 60611-2908, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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Sibley Memorial Hospital
RECRUITINGWashington D.C., District of Columbia, 20016, United States
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University of California, Irvine
RECRUITINGIrvine, California, 92686, United States
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University of Utah, Huntsman Cancer Institute
RECRUITINGSalt Lake City, Utah, 84112-5500, United States
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Conditions
Explore the condition pages connected to this study.