New hope for hard-to-treat cancers: experimental drug targets MTAP-loss tumors
NCT ID NCT06810544
First seen Nov 06, 2025 · Last updated May 16, 2026 · Updated 30 times
Summary
This study tests a new oral drug, TNG456, in people with advanced solid tumors that have lost a gene called MTAP. The drug works by blocking a protein (PRMT5) that these tumors need to grow. The study has two parts: first, finding the safest dose of TNG456 alone or with abemaciclib; second, testing how well it shrinks tumors in specific cancer types. Up to 191 adults whose cancer has worsened after standard treatments may join.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dana Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Mayo Clinic Cancer Center
RECRUITINGRochester, Minnesota, 55905-0001, United States
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Mayo Clinic Jacksonville
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic Scottsdale
RECRUITINGScottsdale, Arizona, 85259-5452, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 11065, United States
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NEXT Virginia
RECRUITINGFairfax, Virginia, 22031, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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Northwestern Memorial Hospital
RECRUITINGChicago, Illinois, 60611-2908, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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Sibley Memorial Hospital
RECRUITINGWashington D.C., District of Columbia, 20016, United States
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University of California Los Angeles
RECRUITINGLos Angeles, California, 90995, United States
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University of California at San Francisco
RECRUITINGSan Francisco, California, 94143-2202, United States
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University of California, Irvine
RECRUITINGIrvine, California, 92686, United States
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University of Utah, Huntsman Cancer Institute
RECRUITINGSalt Lake City, Utah, 84112-5500, United States
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Conditions
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