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Should we operate sooner on enlarged aortas? major trial aims to settle debate

NCT ID NCT03536312

Recruiting now Disease control Sponsor: Ottawa Heart Institute Research Corporation Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at patients with an ascending aorta that is enlarged (5.0 to 5.4 cm) but not yet at the traditional surgery threshold. Half will have early surgery to replace the aorta, and half will be closely monitored. Researchers will compare death rates and dangerous aortic events over two years to see which approach is safer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Thoracic aortic surgery (procedure to replace the enlarged section of the aorta)
What this could lead to
If early surgery proves better, it could guide doctors to operate sooner on patients with moderately enlarged aortas, potentially preventing deadly tears or ruptures.
What could go wrong
This is a mid-stage trial with 610 participants, so results may not apply to everyone. Surgery itself carries risks like death or stroke, and the surveillance group may still need surgery later.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Aneurysm aneurysm or dilatation of ascending aorta Aneurysm, Ascending Aorta

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASCENDING AORTA ANEURYSM ASCENDING AORTIC ANEURYSM ENLARGEMENT

Contacts and locations

Study contacts

  • Contact

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Locations

  • Baylor Scott & White Research Institute

    RECRUITING

    Plano, Texas, 75093, United States

    Contact

  • Beth Israel Deaconess Medical Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Duke University

    RECRUITING

    Durham, North Carolina, 27705, United States

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  • Hamilton General Hospital

    RECRUITING

    Hamilton, Ontario, Canada

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  • Health Sciences North

    RECRUITING

    Greater Sudbury, Ontario, Canada

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  • Horizon Health Network

    RECRUITING

    Saint John, New Brunswick, E2L 4L2, Canada

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  • Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

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  • Institut universitaire de cardiologie et de pneumologie de Québec

    RECRUITING

    Québec, Quebec, G1V 4G5, Canada

    Contact

  • London Health Sciences Centre

    RECRUITING

    London, Ontario, N6A 5A5, Canada

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  • MUSC Health University Medical Center

    RECRUITING

    Charleston, South Carolina, 29425, United States

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  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

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  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • Mazankowski Alberta Heart Institute

    RECRUITING

    Edmonton, Alberta, T6G 0M9, Canada

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    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • McGill University Health Centre

    RECRUITING

    Montreal, Quebec, H3H2R9, Canada

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  • Montreal Heart Institute

    RECRUITING

    Montreal, Quebec, H1T 1C8, Canada

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  • Nova Scotia Health Authority

    RECRUITING

    Halifax, Nova Scotia, B3S 0H6, Canada

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    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Ohio State University Medical Center

    RECRUITING

    Columbus, Ohio, 43210, United States

    Contact

  • St. Michael's Hospital

    NOT_YET_RECRUITING

    Toronto, Ontario, M5B 1W8, Canada

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  • The Trustees of the University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact

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  • The Valley Hospital, Inc

    RECRUITING

    Ridgewood, New Jersey, 07652, United States

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  • Toronto General Hospital

    RECRUITING

    Toronto, Ontario, Canada

    Contact

  • University Hospitals Cleveland

    RECRUITING

    Cleveland, Ohio, 44106, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Calgary

    RECRUITING

    Calgary, Alberta, T2N 2T9, Canada

    Contact

    Contact

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  • University of California at San Francisco Medical Center

    RECRUITING

    San Francisco, California, 94121, United States

    Contact

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

    Contact

    Contact

  • University of Ottawa Heart Institute

    RECRUITING

    Ottawa, Ontario, K1Y 4W7, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • University of Texas Health Science Centre

    RECRUITING

    Houston, Texas, 77030, United States

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  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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