New hope for advanced cervical cancer: targeted drug combo shows promise

NCT ID NCT03786081

Terminated Disease control Sponsor: Seagen, a wholly owned subsidiary of Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This trial tested a drug called tisotumab vedotin, alone or with other medicines, in people with cervical cancer that had come back or spread. The study included 214 participants and aimed to find the best dose and see if the tumors shrank. The trial was stopped early, but the results help guide future treatments for advanced cervical cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cervical cancer Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CANCER

Contacts and locations

Locations

AMC Medical Research

Amsterdam, Netherlands
AZ Sint-Jan

Bruges, 8000, Belgium
Amsterdam UMC, Locatie AMC

Amsterdam, 1105 AZ, Netherlands
Arizona Oncology Associates

Phoenix, Arizona, 85016, United States
Augusta University

Augusta, Georgia, 30912, United States
Azienda Ospedaliera Cannizzaro

Catania, 95100, Italy
Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States
Baskent University Adana Application and Research Center

Adana, 01220, Turkey (Türkiye)
Baskent University Ankara Hospital

Ankara, 06490, Turkey (Türkiye)
Beatson West of Scotland Cancer Centre

Glasgow, Strathclyde, G12 OYN, United Kingdom
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Brown University - Women's and Infant Hospital

Providence, Rhode Island, 02905, United States
CHU UCL Namur

Namur, 5000, Belgium
Carilion Clinic

Roanoke, Virginia, 24016, United States
Centre Hospitalier Universitaire (CHU) de Liège

Liège, 4000, Belgium
Centre Hospitalier de l'Ardenne

Libramont, 6800, Belgium
Cleveland Clinic

Cleveland, Ohio, 44106, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cliniques universitaires Saint-Luc

Brussels, 1200, Belgium
Cork University Hospital

Cork, Ireland
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Erasmus Medisch Centrum

Rotterdam, 3015 CC, Netherlands
Erasmus University Medical Center Rotterdam

Rotterdam, 3015, Netherlands
Fakultni nemocnice Bulovka

Prague, 180 81, Czechia
Fakultni nemocnice Olomouc

Olomouc, 775 20, Czechia
Fakultni nemocnice Olomouc

Olomouc, 77520, Czechia
Fakultni nemocnice Ostrava

Ostrava-Poruba, 70852, Czechia
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, 00168, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Rome, 00168, Italy
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Grand Hôpital de Charleroi

Charleroi, 6000, Belgium
Grand Hôpital de Charleroi

Loverval, 6280, Belgium
Hospital 12 De Octubre

Madrid, 28041, Spain
Hospital Universitari Vall d'Hebron

Barcelona, 8035, Spain
Hospital Universitario Reina Sofia

Córdoba, 14004, Spain
Hospital Universitario Virgen de la Arrixaca

El Palmar, 30120, Spain
Huntsman Cancer Center

Salt Lake City, Utah, 84112, United States
IEO Istituto Europeo di Oncologia

Milan, 20141, Italy
Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States
Istituto Nazionale Tumori Fondazione G. Pascale

Naples, 80131, Italy
Magee-Womens Hospital of UPMC

Pittsburgh, Pennsylvania, 15213, United States
Mater Misericordiae University Hospital

Dublin, D07 R2WY, Ireland
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Montana Cancer Consortium

Billings, Montana, 59102, United States
Nemocnice Na Bulovce

Prague, 18081, Czechia
Ohio State University Wexner Medical Center

Hilliard, Ohio, 43026, United States
Olive View - UCLA Research and Education Institute

Sylmar, California, 91342, United States
Oschner Clinic

New Orleans, Louisiana, 70121, United States
Radboudumc

Nijmegen, 6525 GA, Netherlands
Rigshospitalet

Copenhagen, 5072, Denmark
Royal Marsden Hospital- Sutton

Sutton, Surrey, SM2 5PT, United Kingdom
SUNY Downstate Medical Center

Brooklyn, New York, 11203, United States
Sainte-Elisabeth

Namur, 5000, Belgium
St Francis Hospital Cancer Center

Greenville, South Carolina, 29607, United States
UMC Utrecht

Utrecht, 3508 GA, Netherlands
UZ Leuven

Leuven, 3000, Belgium
Univ California, Irvine Medical Center

Orange, California, 92868, United States
Universitair Medisch Centrum Groningen (UMCG)

Groningen, 9713 GZ, Netherlands
Universitair Ziekenhuis Antwerpen (UZA)

Edegem, 2650, Belgium
Universitair Ziekenhuis Gent

Ghent, 9000, Belgium
Universitaire Ziekenhuizen Leuven,

Leuven, Belgium
University Hospital Waterford

Waterford, Ireland
University Medical Center Utrecht (UMC Utrecht)

Utrecht, 3584, Netherlands
University of Chicago

Chicago, Illinois, 60525, United States
University of Cincinnati Physicians Group

Cincinnati, Ohio, 45206, United States
University of Kansas Medical Center

Westwood, Kansas, 66205, United States
University of North Carolina Chapel Hill

Chapel Hill, North Carolina, 27514, United States
Velindre Cancer Centre

Cardiff, South Glamorgan, CF14 2TL, United Kingdom
Vseobecna fakultni nemocnice v Praze

Prague, 128 51, Czechia
Vseobecna fakultni nemocnice v Praze

Prague, 12851, Czechia
Waterford Regional Hospital

Waterford, X91 ER8E, Ireland

More trials for these conditions

Other studies related to the condition(s) this trial covers.