New hope for lung cancer: immunotherapy cocktail under study

NCT ID NCT05635708

Ongoing Disease control Sponsor: BeiGene Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing whether combining the immunotherapy drug tislelizumab with other experimental drugs, with or without chemotherapy, can shrink tumors and control advanced non-small cell lung cancer. About 400 people who have not had prior treatment for metastatic disease will participate. The study is divided into two groups based on a protein marker (PD-L1) level to see which combinations work best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tislelizumab (an immunotherapy drug) combined with other investigational drugs and/or chemotherapy
What this could lead to: If successful, this could lead to better treatment options for people with advanced lung cancer, potentially improving tumor shrinkage and delaying disease progression.
What could go wrong: This is an early-phase trial with a small number of participants, so results may not apply to everyone. The combination therapies may cause side effects or not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Affiliated Hospital of Hebei University

Baoding, Hebei, 071000, China
Affiliated Zhongshan Hospital of Fudan University

Shanghai, Shanghai Municipality, 200032, China
Arensia Exploratory Medicine Llc

Tbilisi, 0112, Georgia
Arensia Research Clinic At the Oncology Institute Prof Dr Ion Chiricu

ClujNapoca, 400015, Romania
Asan Medical Center

SongpaGu, Seoul Teugbyeolsi, 05505, South Korea
Blacktown Cancer and Haematology Centre

Blacktown, New South Wales, NSW 2148, Australia
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus

Porto Alegre, 90110-270, Brazil
Centro Ricerche Cliniche Di Verona

Verona, 37126, Italy
Chris Obrien Lifehouse

Camperdown, New South Wales, NSW 2050, Australia
Chu Nantes Hopital Nord Laennec

SaintHerblain, 44805, France
Chungbuk National University Hospital

Cheongju-si, Chungcheongbukdo, 28644, South Korea
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Fujian Cancer Hospital

Fuzhou, Fujian, 350014, China
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto

São José do Rio Preto, 15090-000, Brazil
Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, 150000, China
Henan Cancer Hospital

Zhengzhou, Henan, 450000, China
Hospital Do Cancer de Londrina

Londrina, 86015-520, Brazil
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Vall Dhebron

Barcelona, 08035, Spain
Hospital Universitario Virgen Del Rocio

Seville, 41013, Spain
Hospital de Amor Barretos

Barretos, 14784-400, Brazil
Hrh Princess Maha Chakri Sirindhorn Medical Center (Srinakharinwirot University)

Ongkharak, 26120, Thailand
Hubei Cancer Hospital

Wuhan, Hubei, 430079, China
Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira

São Paulo, 01246-000, Brazil
Institut Curie

Paris, 75005, France
Institute of Oncology Bucharest Prof Dr Alexandru Trestioreanu

Bucureti, 022328, Romania
Jining No1 Peoples Hospital East Branch

Jining, Shandong, 272002, China
Linyi Peoples Hospital

Linyi, Shandong, 276000, China
Maharaj Nakorn Chiang Mai Hospital (Chiang Mai University)

Muang, 50200, Thailand
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center Mskcc

New York, New York, 10065-6800, United States
Nantong Tumor Hospital Branch North

Nantong, Jiangsu, 226000, China
National Cancer Center (Korea)

IlsandongGu GoyangSi, Gyeonggi-do, 10408, South Korea
National Cancer Centre Singapore

Singapore, 168583, Singapore
Northern Beaches Hospital

Frenchs Forest, New South Wales, NSW 2086, Australia
One Clinical Research

Nedlands, Western Australia, WA 6009, Australia
Port Macquarie Base Hospital

Port Macquarie, New South Wales, NSW 2444, Australia
Providence Portland Medical Center

Portland, Oregon, 97213-2933, United States
Pulau Pinang Hospital

George Town, 10450, Malaysia
Regina Elena, Istituto Nazionale Dei Tumori, Ifo, Irccs

Roma, 00144, Italy
Samsung Medical Center

GangnamGu, Seoul Teugbyeolsi, 06351, South Korea
Sarawak General Hospital

Kuching, 93586, Malaysia
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea
Severance Hospital Yonsei University Health System

SeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea
Shanghai East Hospital Branch Hospital

Shanghai, Shanghai Municipality, 200123, China
Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, 200433, China
Shanxi Provincial Cancer Hospital

Taiyuan, Shanxi, 030013, China
Songklanagarind Hospital (Prince of Songkhla University)

Hat Yai, 90110, Thailand
Srinagarind Hospital (Khon Kaen University)

Muang, 40002, Thailand
St John of God Health Care

Subiaco, Western Australia, WA 6008, Australia
Taizhou Hospital of Zhejiang

Taizhou, Zhejiang, 317000, China
Tengku Ampuan Afzan Hospital

Kuantan, 25100, Malaysia
The Catholic University of Korea, St Vincents Hospital

PaldalGu SuwonSi, Gyeonggi-do, 16247, South Korea
The Fifth Medical Center of Chinese Pla General Hospital

Beijing, Beijing Municipality, 100071, China
The First Affiliated Hospital of Nanchang University Branch Xianghu

Nanchang, Jiangxi, 332000, China
The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, 215006, China
The Institute of Oncology, Arensia Exploratory Medicine

Chisinau, 2025, Moldova
The Second Hospital of Anhui Medical University

Hefei, Anhui, 230601, China
The University of Texas Md Anderson Cancer Center

Houston, Texas, 77030-4009, United States
Tianjin Medical University Cancer Institute and Hospital

Tianjin, Tianjin Municipality, 300060, China
Valkyrie Clinical Trials

Los Angeles, California, 90067-2011, United States

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