Could a 14-Hour daily fast sharpen the aging brain?
NCT ID NCT05488652
First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time
Summary
This study explores whether time-restricted eating—fasting for 14 hours each day—can improve blood vessel function in the brain and enhance cognitive performance in older adults. Participants will follow this eating pattern while researchers measure brain blood flow responses and retinal vessel dilation. The goal is to see if this dietary approach might support healthier brain aging.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Time-restricted eating (14:10 daily fasting regimen)
- What this could lead to
- If successful, this could point toward a simple dietary approach to support brain health and cognitive function in aging.
- What could go wrong
- This is a small, early-stage study, so results may not apply broadly. The dietary change may be hard to sustain, and benefits are not guaranteed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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11 people
The number who actually took part.
- Started
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Nov 2022
- Finished
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Jan 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥21 years * Adequate hearing and visual acuity to participate in examinations * Ability to read and write in English * Competence to provide informed consent Exclusion Criteria: * Vision or hearing impairment that would impair the ability to complete study assessments * Active CNS disease including multiple sclerosis, uncontrolled seizures, and active brain cancer * Cerebrovascular accident other than TIA within 60 days prior to screening * Any other medical condition which, in the opinion of the investigator, would render the participant inappropriate or too unstable to complete the study protocol
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73117, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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