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PCOS drug trial halted early: did tildacerfont lower hormones?

NCT ID NCT05370521

Terminated Disease control Sponsor: Spruce Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called tildacerfont in 27 women with polycystic ovary syndrome (PCOS) who had high levels of adrenal androgens (hormones). The goal was to see if the drug could safely lower these hormones. The trial was stopped early, so results are limited.

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Conditions

The condition(s) this trial relates to.

adrenal gland disorder polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POLYCYSTIC OVARY SYNDROME

Contacts and locations

Locations

  • Spruce Study Site

    Sacramento, California, 95817, United States

  • Spruce Study Site

    San Francisco, California, 94158, United States

  • Spruce Study Site

    New Haven, Connecticut, 06519, United States

  • Spruce Study Site

    Clearwater, Florida, 33759, United States

  • Spruce Study Site

    Lake Worth, Florida, 33461, United States

  • Spruce Study Site

    Miami, Florida, 33173, United States

  • Spruce Study Site

    Winter Park, Florida, 32792, United States

  • Spruce Study Site

    Idaho Falls, Idaho, 83404, United States

  • Spruce Study Site

    Wichita, Kansas, 67226, United States

  • Spruce Study Site

    Boston, Massachusetts, 02115, United States

  • Spruce Study Site

    Fall River, Massachusetts, 02720, United States

  • Spruce Study Site

    Southfield, Michigan, 48034, United States

  • Spruce Study Site

    Williamsville, New York, 14221, United States

  • Spruce Study Site

    Raleigh, North Carolina, 27612, United States

  • Spruce Study Site

    Cincinnati, Ohio, 45219, United States

  • Spruce Study Site

    Cleveland, Ohio, 44106, United States

  • Spruce Study Site

    Philadelphia, Pennsylvania, 19104, United States

  • Spruce Study Site

    Bedford, Texas, 76022, United States

  • Spruce Study Site

    Houston, Texas, 77024, United States

  • Spruce Study Site

    Houston, Texas, 77030, United States

  • Spruce Study Site

    Morgantown, West Virginia, 26506, United States

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