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Can a simple supplement boost IVF success in PCOS?

NCT ID NCT07779850

Disease control Sponsor: Kafrelsheikh University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial tests whether myo-inositol, a natural supplement, can improve fertility treatment outcomes in women with polycystic ovary syndrome (PCOS). Participants take myo-inositol with folic acid or folic acid alone for three months before IVF or ICSI. The study measures egg quality, fertilization rates, and pregnancy outcomes to see if the supplement helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Myo-inositol (a dietary supplement) combined with folic acid
What this could lead to
If effective, myo-inositol could become a simple, low-cost supplement to improve egg quality and pregnancy rates in women with PCOS undergoing IVF.
What could go wrong
This is a small, early-stage trial, and results may not apply to all women. The supplement may not improve outcomes, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

88 people

The number who actually took part.

Started

May 2024

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female participants aged 18 to 40 years. * Diagnosis of polycystic ovary syndrome (PCOS) according to the Rotterdam criteria. * Normal thyroid hormone levels. * Normal prolactin levels. * Candidates for in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). Exclusion Criteria: * Previous ovarian surgery. * History of endometrioma. * History of endocrine disease, including congenital adrenal hyperplasia or diabetes mellitus. * Smoking. * Known allergy to myo-inositol. * Current use of oral contraceptive pills. * Receipt of hormonal medications within the 3 months before study enrollment. * Refusal to participate in the study.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance ovarian hyperstimulation syndrome polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Polycystic ovary syndrome

Contacts and locations

Locations

  • Kafr-Elsheikh University Hospital

    Kafr ash Shaykh, Kafr el-Sheikh Governorate, 33511, Egypt

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