New hope for tough thyroid cancers that resist standard treatments

NCT ID NCT03690388

Ongoing Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

Summary

This study tested whether the drug cabozantinib could help control advanced thyroid cancer that no longer responds to radioactive iodine or certain targeted therapies. It involved 187 patients whose cancer had worsened despite previous treatment. Participants were randomly assigned to receive either cabozantinib or a placebo pill to compare how long their cancer remained stable.

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Contacts and locations

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Locations

Exelixis Clinical Site #1

Philadelphia, Pennsylvania, 19104, United States
Exelixis Clinical Site #10

Stanford, California, 94305, United States
Exelixis Clinical Site #100

Ghent, 9000, Belgium
Exelixis Clinical Site #101

Taipei, 11490, Taiwan
Exelixis Clinical Site #102

Besançon, 25030, France
Exelixis Clinical Site #103

Milan, 20133, Italy
Exelixis Clinical Site #104

Olomouc, 779 00, Czechia
Exelixis Clinical Site #105

Brno, 656 53, Czechia
Exelixis Clinical Site #106

Omsk, 644013, Russia
Exelixis Clinical Site #107

London, Ontario, N6A 5W9, Canada
Exelixis Clinical Site #108

Naples, 80131, Italy
Exelixis Clinical Site #109

Viagrande, Catania, 95029, Italy
Exelixis Clinical Site #11

Omaha, Nebraska, 68114, United States
Exelixis Clinical Site #110

Milan, 20141, Italy
Exelixis Clinical Site #111

Siena, 53100, Italy
Exelixis Clinical Site #112

Tainan, 71004, Taiwan
Exelixis Clinical Site #113

Seattle, Washington, 98109, United States
Exelixis Clinical Site #114

Madrid, 28027, Spain
Exelixis Clinical Site #115

Milan, 20149, Italy
Exelixis Clinical Site #116

Ribeirão Preto, São Paulo, 14051-140, Brazil
Exelixis Clinical Site #117

Leiden, South Holland, 2333 ZA, Netherlands
Exelixis Clinical Site #118

Morristown, New Jersey, 07962, United States
Exelixis Clinical Site #119

Vienna, 1090, Austria
Exelixis Clinical Site #12

Herston, 4029, Australia
Exelixis Clinical Site #120

Torino, TO, 10126, Italy
Exelixis Clinical Site #121

Tübingen, Baden-Wurttemberg, 72076, Germany
Exelixis Clinical Site #122

Pathum Wan, Bangkok, 10330, Thailand
Exelixis Clinical Site #123

Padua, 35128, Italy
Exelixis Clinical Site #124

Magdeburg, Saxony-Anhalt, 39120, Germany
Exelixis Clinical Site #125

Marburg, Hesse, 35043, Germany
Exelixis Clinical Site #126

Bangkok Noi, Bangkok, 10700, Thailand
Exelixis Clinical Site #127

Roma, 00161, Italy
Exelixis Clinical Site #128

Amsterdam, North Holland, 1081 HV, Netherlands
Exelixis Clinical Site #129

Córdoba, X5000AVE, Argentina
Exelixis Clinical Site #13

Madrid, 28034, Spain
Exelixis Clinical Site #130

Hat Yai, Changwat Songkhla, 90110, Thailand
Exelixis Clinical Site #131

Bonn, 53127, Germany
Exelixis Clinical Site #132

Meldola, Forlì - Cesena, 47017, Italy
Exelixis Clinical Site #133

Ciudad de Mèxico, 06100, Mexico
Exelixis Clinical Site #134

Charleston, South Carolina, 29425, United States
Exelixis Clinical Site #135

Catania, CT, 95122, Italy
Exelixis Clinical Site #136

Tainan, 704, Taiwan
Exelixis Clinical Site #137

Zagreb, 10000, Croatia
Exelixis Clinical Site #138

Zagreb, 10000, Croatia
Exelixis Clinical Site #139

München, 81377, Germany
Exelixis Clinical Site #14

Barcelona, 08035, Spain
Exelixis Clinical Site #140

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
Exelixis Clinical Site #141

Ratchathewi, Bangkok, 10400, Thailand
Exelixis Clinical Site #142

Timișoara, Timiș County, 300166, Romania
Exelixis Clinical Site #143

Rozzano, Milano, 20089, Italy
Exelixis Clinical Site #144

Genova, GE, 16132, Italy
Exelixis Clinical Site #145

Osijek, 31000, Croatia
Exelixis Clinical Site #146

Bucharest, 011863, Romania
Exelixis Clinical Site #147

Mexico City, 03100, Mexico
Exelixis Clinical Site #148

Mexico City, 06700, Mexico
Exelixis Clinical Site #149

Cluj-Napoca, Cluj, 400015, Romania
Exelixis Clinical Site #15

Warsaw, Masovian Voivodeship, 02-781, Poland
Exelixis Clinical Site #150

Craiova, Dolj, 200385, Romania
Exelixis Clinical Site #151

Dresden, Saxony, 01307, Germany
Exelixis Clinical Site #152

Paris, 75013, France
Exelixis Clinical Site #153

Boston, Massachusetts, 02114, United States
Exelixis Clinical Site #154

Essen, 45147, Germany
Exelixis Clinical Site #155

Aachen, 52074, Germany
Exelixis Clinical Site #156

Würzburg, Bavaria, 97080, Germany
Exelixis Clinical Site #157

Tyumen, Tyumen Oblast, 625041, Russia
Exelixis Clinical Site #158

Tuxtla Gutiérrez, Chiapas, 29038, Mexico
Exelixis Clinical Site #159

Hamburg, 20246, Germany
Exelixis Clinical Site #16

Madrid, 28040, Spain
Exelixis Clinical Site #160

Freiburg im Breisgau, 79106, Germany
Exelixis Clinical Site #161

San Luis Potosí City, 78200, Mexico
Exelixis Clinical Site #162

London, England, SW3 6JJ, United Kingdom
Exelixis Clinical Site #163

Hanover, Lower Saxony, 30625, Germany
Exelixis Clinical Site #164

Chicago, Illinois, 60637, United States
Exelixis Clinical Site #17

St Leonards, New South Wales, 2065, Australia
Exelixis Clinical Site #18

Edmonton, Alberta, T6G 1Z2, Canada
Exelixis Clinical Site #19

Durham, North Carolina, 27710, United States
Exelixis Clinical Site #2

Newport Beach, California, 92658, United States
Exelixis Clinical Site #20

Calgary, Alberta, T2N 4N2, Canada
Exelixis Clinical Site #21

New Haven, Connecticut, 06510, United States
Exelixis Clinical Site #22

Detroit, Michigan, 48202, United States
Exelixis Clinical Site #23

Madrid, 28050, Spain
Exelixis Clinical Site #24

Melbourne, Victoria, 3004, Australia
Exelixis Clinical Site #25

Waratah, New South Wales, 2298, Australia
Exelixis Clinical Site #26

Edegem, 2650, Belgium
Exelixis Clinical Site #27

Namur, 5000, Belgium
Exelixis Clinical Site #28

Hong Kong, Hong Kong
Exelixis Clinical Site #29

Pisa, PI, 56124, Italy
Exelixis Clinical Site #3

Torrance, California, 90502, United States
Exelixis Clinical Site #30

Madrid, 28033, Spain
Exelixis Clinical Site #31

Brussels, 1200, Belgium
Exelixis Clinical Site #32

Dijon, Bourgogne-Franche-Comté, 21079, France
Exelixis Clinical Site #33

Madrid, 28041, Spain
Exelixis Clinical Site #34

Seoul, 05505, South Korea
Exelixis Clinical Site #35

Cascavel, Paraná, 85806-300, Brazil
Exelixis Clinical Site #36

Seoul, 03080, South Korea
Exelixis Clinical Site #37

Pécs, 7624, Hungary
Exelixis Clinical Site #38

Porto Alegre, Rio Grande do Sul, 90110-270, Brazil
Exelixis Clinical Site #39

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Exelixis Clinical Site #4

Washington D.C., District of Columbia, 20010, United States
Exelixis Clinical Site #40

São José do Rio Preto, São Paulo, 15090-000, Brazil
Exelixis Clinical Site #41

Jerusalem, 9112001, Israel
Exelixis Clinical Site #42

St Louis, Missouri, 63110, United States
Exelixis Clinical Site #43

Haifa, 3109601, Israel
Exelixis Clinical Site #44

Villejuif, Île-de-France Region, 94805, France
Exelixis Clinical Site #45

Angers, Pays de la Loire Region, 4933, France
Exelixis Clinical Site #46

Budapest, 1122, Hungary
Exelixis Clinical Site #47

São Paulo, 01246-000, Brazil
Exelixis Clinical Site #48

Obninsk, Kaluzhiskiy Region, 249036, Russia
Exelixis Clinical Site #49

Moscow, 117036, Russia
Exelixis Clinical Site #5

Bethlehem, Pennsylvania, 18015, United States
Exelixis Clinical Site #50

Glasgow, Scotland, G12 0YN, United Kingdom
Exelixis Clinical Site #51

Oxford, England, OX3 7LE, United Kingdom
Exelixis Clinical Site #52

Samara, 443031, Russia
Exelixis Clinical Site #53

Moscow, 121309, Russia
Exelixis Clinical Site #54

Lexington, Kentucky, 40536, United States
Exelixis Clinical Site #55

Kislino, Kursk Oblast, 305524, Russia
Exelixis Clinical Site #56

Naples, 80131, Italy
Exelixis Clinical Site #57

Sheffield, S10 2SJ, United Kingdom
Exelixis Clinical Site #58

Petah Tikva, 4941492, Israel
Exelixis Clinical Site #59

Poznan, Greater Poland Voivodeship, 60-355, Poland
Exelixis Clinical Site #6

Tampa, Florida, 33612, United States
Exelixis Clinical Site #60

Cardiff, Wales, CF14 2TL, United Kingdom
Exelixis Clinical Site #61

Gliwice, Silesian Voivodeship, 44-101, Poland
Exelixis Clinical Site #62

Salzburg, 5020, Austria
Exelixis Clinical Site #63

Columbia, Missouri, 65212, United States
Exelixis Clinical Site #64

Aberdeen, Scotland, AB25 2ZN, United Kingdom
Exelixis Clinical Site #65

Manchester, M20 4BX, United Kingdom
Exelixis Clinical Site #66

Yaroslavl, 150054, Russia
Exelixis Clinical Site #67

Bordeaux, Nouvelle-Aquitaine, 33075, France
Exelixis Clinical Site #68

Nashville, Tennessee, 37232, United States
Exelixis Clinical Site #69

San Francisco, California, 94115, United States
Exelixis Clinical Site #7

Cincinnati, Ohio, 45219, United States
Exelixis Clinical Site #70

Busan, 49267, South Korea
Exelixis Clinical Site #71

Bristol, England, BS2 8ED, United Kingdom
Exelixis Clinical Site #72

Marseille, Provence-Alpes-Côte d'Azur Region, 13915, France
Exelixis Clinical Site #73

Madrid, 28046, Spain
Exelixis Clinical Site #74

Edegem, 2650, Belgium
Exelixis Clinical Site #75

Pittsburgh, Pennsylvania, 15232, United States
Exelixis Clinical Site #76

Charlotte, North Carolina, 28204, United States
Exelixis Clinical Site #77

Taipei, 10002, Taiwan
Exelixis Clinical Site #78

Detroit, Michigan, 48201, United States
Exelixis Clinical Site #79

Gyeonggi-do, 10408, South Korea
Exelixis Clinical Site #8

Houston, Texas, 77030, United States
Exelixis Clinical Site #80

Ann Arbor, Michigan, 48109, United States
Exelixis Clinical Site #81

Málaga, 29010, Spain
Exelixis Clinical Site #82

Nice, 06189, France
Exelixis Clinical Site #83

Toronto, Ontario, M5G 2M9, Canada
Exelixis Clinical Site #84

Moscow, 125284, Russia
Exelixis Clinical Site #85

Moscow, 155478, Russia
Exelixis Clinical Site #86

Bedford Park, South Australia, 5042, Australia
Exelixis Clinical Site #87

Roma, 00144, Italy
Exelixis Clinical Site #88

Birmingham, England, B15 2TH, United Kingdom
Exelixis Clinical Site #89

Saint Petersburg, 198255, Russia
Exelixis Clinical Site #9

Aurora, Colorado, 80045, United States
Exelixis Clinical Site #90

Anderlecht, 1070, Belgium
Exelixis Clinical Site #91

Lyon, 69373, France
Exelixis Clinical Site #92

Rio de Janeiro, 20231-050, Brazil
Exelixis Clinical Site #93

Orlando, Florida, 32804, United States
Exelixis Clinical Site #94

Miami, Florida, 33136, United States
Exelixis Clinical Site #95

Strasbourg, 67065, France
Exelixis Clinical Site #96

Pergamino, Buenos Aires, B2700CPM, Argentina
Exelixis Clinical Site #97

Caba, C1012AAR, Argentina
Exelixis Clinical Site #98

Sacramento, California, 95817, United States
Exelixis Clinical Site #99

Barcelona, 08036, Spain

Conditions

Explore the condition pages connected to this study.

DIFFERENTIATED THYROID CANCER