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Can a vitamin boost Babies' brains before birth?

NCT ID NCT07795996

Prevention Sponsor: Mount Saint Vincent University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

This trial tests whether giving pregnant women a higher dose of thiamine (vitamin B1) than usual, starting early in pregnancy and continuing through infancy, improves brain development in their children. Researchers will enroll about 2,000 pregnant women in Cambodia, where low thiamine intake is common because white rice is a staple food. Half will receive the standard amount of thiamine in a multiple micronutrient supplement, and half will receive a higher dose. The main goal is to measure cognitive development at 18 months of age using a standard early learning test.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Multiple micronutrient supplements with a higher dose of thiamine (vitamin B1), given to pregnant women and then to infants as liquid drops.
What this could lead to
If higher thiamine intake during pregnancy and early life improves infant cognition, it could point to a simple, low-cost way to support brain development in regions where thiamine deficiency is common.
What could go wrong
This is an early-stage trial, and the previous study only showed benefits when supplementation started after birth. Starting earlier may not add extra benefit, and the results may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,972 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

This community-based trial will take place in villages throughout Kampong Thom province, Cambodia. Using convenience sampling, pregnant women (either primi- or multi-gravida) will be recruited from antenatal care programs within local health centers in Kampong Thom province. Inclusion Criteria: * women aged 18-45 years * 12(+0) to 15(+6) weeks pregnant, based on last menstrual period * planning to breastfeed for at least 6 months Exclusion Criteria: * consumed thiamine-containing supplements in the preceding 3 months * planning on moving out of province in the next year

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neurocognition, child

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Community-based study

    RECRUITING

    Kampong Thom, Cambodia

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