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Cannabis compound tested as a way to soften painful memories

NCT ID NCT06471647

Symptom relief Sponsor: University of Chicago Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This early-phase trial investigates whether delta-9-tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, can reduce the emotional and physical responses triggered by recalling stressful experiences. Healthy adults aged 18–35 with some prior cannabis use will receive either a low or moderate dose of THC or a placebo before being exposed to cues linked to a stressful memory. Researchers will measure self-reported distress and heart-related responses to see if THC dampens the reaction, both immediately and one week later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
delta-9-tetrahydrocannabinol (THC)
What this could lead to
If THC dampens the emotional sting of bad memories, it could point toward a new way to treat conditions like PTSD.
What could go wrong
This is a very early, small study in healthy volunteers, so results may not apply to people with mental health conditions. THC can also cause anxiety or paranoia in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

36 people

The number who actually took part.

Started

Jul 2024

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-35 y/o * BMI 19-29 kg/m2 * some prior experience with cannabis (used at least 4 times, no adverse experiences, and current use no more than once a week) Exclusion Criteria: * Current severe substance use disorder * history of psychosis or mania * Lack of English fluency * Current DSM IV Axis I disorder * Abnormal EKG * Daily use of medications outside of contraception, * Women who are pregnant or trying to become pregnant

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Delta-9-tetrahydrocannabinol (THC) Stress

Contacts and locations

Locations

  • University of Chicago

    Chicago, Illinois, 60637, United States

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