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New injection shows promise for stubborn nasal polyps

NCT ID NCT04851964

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jan 31, 2026 · Last updated Apr 20, 2026 · Updated 8 times

Summary

This study tested whether a medication called tezepelumab, given as an injection, could reduce nasal polyps and improve symptoms in people with severe chronic sinusitis. Over 400 participants with severe symptoms who needed surgery received either the drug or a placebo for 52 weeks. Researchers measured changes in polyp size and symptoms like nasal congestion and loss of smell.

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Contacts and locations

Locations

  • Research Site

    Birmingham, Alabama, 35209, United States

  • Research Site

    Bakersfield, California, 93301, United States

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    Newport Beach, California, 92663, United States

  • Research Site

    Roseville, California, 95661, United States

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    Walnut Creek, California, 94598, United States

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    Colorado Springs, Colorado, 80923, United States

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    Denver, Colorado, 80230, United States

  • Research Site

    Boca Raton, Florida, 33487, United States

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    Chicago, Illinois, 60657, United States

  • Research Site

    Baltimore, Maryland, 21224, United States

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    White Marsh, Maryland, 21162, United States

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    Boston, Massachusetts, 02115, United States

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    Columbia, Missouri, 65212, United States

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    New York, New York, 10003, United States

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    Winston-Salem, North Carolina, 27103, United States

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    Oklahoma City, Oklahoma, 73120, United States

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    North Charleston, South Carolina, 29406, United States

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    Dallas, Texas, 75231, United States

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    Norfolk, Virginia, 23507, United States

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    Spokane, Washington, 99201, United States

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    Milwaukee, Wisconsin, 53228, United States

  • Research Site

    Vancouver, British Columbia, V6Z 1Y6, Canada

  • Research Site

    Hamilton, Ontario, L8S 1G5, Canada

  • Research Site

    London, Ontario, N6A 4V2, Canada

  • Research Site

    Montreal, Quebec, H2V 2K1, Canada

  • Research Site

    Montreal, Quebec, H2X 0A9, Canada

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    Montreal, Quebec, H4A 3J1, Canada

  • Research Site

    Québec, Quebec, G1S 4L8, Canada

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    Québec, Quebec, G1V 4G5, Canada

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    Québec, Quebec, G1V 4W2, Canada

  • Research Site

    Trois-Rivières, Quebec, G8T 7A1, Canada

  • Research Site

    Bengbu, 233004, China

  • Research Site

    Chengdu, 610072, China

  • Research Site

    Guangzhou, 510120, China

  • Research Site

    Hangzhou, 310003, China

  • Research Site

    Hangzhou, 310014, China

  • Research Site

    Hengyang, 421001, China

  • Research Site

    Lanzhou, 730030, China

  • Research Site

    Nanchang, 330006, China

  • Research Site

    Nanjing, 210009, China

  • Research Site

    Qingdao, 266011, China

  • Research Site

    Shanghai, 200031, China

  • Research Site

    Shanghai, 200433, China

  • Research Site

    Suzhou, 215006, China

  • Research Site

    Taizhou, 225300, China

  • Research Site

    Tianjin, 300121, China

  • Research Site

    Tianjin, 300211, China

  • Research Site

    Wenzhou, 325027, China

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    Wuhan, 430060, China

  • Research Site

    Xi'an, 710068, China

  • Research Site

    Yinchuan, 750001, China

  • Research Site

    Zunyi, 563100, China

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    Aalborg, 9000, Denmark

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    Aarhus N, 8200, Denmark

  • Research Site

    Hillerød, 3400, Denmark

  • Research Site

    Hvidovre, 2650, Denmark

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    København NV, 2400, Denmark

  • Research Site

    Køge, 4600, Denmark

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    Odense, 5000, Denmark

  • Research Site

    Vejle, 7100, Denmark

  • Research Site

    Berlin, 10629, Germany

  • Research Site

    Berlin, 13353, Germany

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    Dresden, 01307, Germany

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    Heidelberg, 69120, Germany

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    Lübeck, 23538, Germany

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    Marburg, 35043, Germany

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    Tübingen, 72076, Germany

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    Wiesbaden, 65183, Germany

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    Budapest, 1046, Hungary

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    Budapest, 1083, Hungary

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    Budapest, 1134, Hungary

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    Nyíregyháza, 4400, Hungary

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    Pécs, 7621, Hungary

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    Siófok, 8600, Hungary

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    Székesfehérvár, 8000, Hungary

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    Bunkyō City, 113-8431, Japan

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    Chuo-shi, 409-3898, Japan

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    Habikino-shi, 583-0886, Japan

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    Ichikawa-shi, 272-0111, Japan

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    Itabashi-ku, 173-8610, Japan

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    Kashiwa-shi, 277-0882, Japan

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    Kisarazu-shi, 292-8535, Japan

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    Miyazaki, 880-8510, Japan

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    Nagaoka-shi, 940-8621, Japan

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    Nerima-ku, 177-0035, Japan

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    Niigata, 951-8520, Japan

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    Osaka, 553-0003, Japan

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    Saitama-shi, 336-8522, Japan

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    Sapporo, 003-0022, Japan

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    Sendai, 983-8512, Japan

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    Suwa-shi, 392-8510, Japan

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    Toyonaka Shi, 560-0082, Japan

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    Yokohama, 227-8501, Japan

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    Yokohama, 236-0037, Japan

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    Bialystok, 15-879, Poland

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    Bydgoszcz, 85-231, Poland

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    Krakow, 31-513, Poland

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    Nadarzyn, 05-830, Poland

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    Wroclaw, 50-556, Poland

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    Wroclaw, 53-301, Poland

  • Research Site

    Zawadzkie, 47-120, Poland

  • Research Site

    Łodź, 90-153, Poland

  • Research Site

    Barakaldo, 48903, Spain

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    Barcelona, 08036, Spain

  • Research Site

    Jerez de la Frontera, 11407, Spain

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    Madrid, 28040, Spain

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    Santiago de Compostela, 15706, Spain

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    Seville, 41009, Spain

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    Dundee, DD1 9SY, United Kingdom

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    London, SE1 9RT, United Kingdom

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    Manchester, M13 9WL, United Kingdom

  • Research Site

    Stockport, SK2 7JE, United Kingdom

Conditions

Explore the condition pages connected to this study.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPS