New injection aims to shrink stubborn nasal polyps, reduce need for surgery

NCT ID NCT04851964

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large, completed Phase 3 trial tested whether a new injectable medication called tezepelumab could help adults with severe, long-term sinusitis and large nasal polyps. Over 400 participants received either tezepelumab or a placebo shot every four weeks for a year, while continuing their standard nasal spray. The main goals were to see if the drug could shrink the polyps, ease congestion and other symptoms, and reduce the need for surgery or steroid pills.

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Contacts and locations

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Locations

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Birmingham, Alabama, 35209, United States
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Bakersfield, California, 93301, United States
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Newport Beach, California, 92663, United States
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Roseville, California, 95661, United States
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Walnut Creek, California, 94598, United States
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Colorado Springs, Colorado, 80923, United States
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Denver, Colorado, 80230, United States
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Boca Raton, Florida, 33487, United States
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Chicago, Illinois, 60657, United States
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Baltimore, Maryland, 21224, United States
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White Marsh, Maryland, 21162, United States
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Boston, Massachusetts, 02115, United States
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Columbia, Missouri, 65212, United States
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New York, New York, 10003, United States
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Winston-Salem, North Carolina, 27103, United States
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Oklahoma City, Oklahoma, 73120, United States
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North Charleston, South Carolina, 29406, United States
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Dallas, Texas, 75231, United States
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Norfolk, Virginia, 23507, United States
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Spokane, Washington, 99201, United States
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Milwaukee, Wisconsin, 53228, United States
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Vancouver, British Columbia, V6Z 1Y6, Canada
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Hamilton, Ontario, L8S 1G5, Canada
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London, Ontario, N6A 4V2, Canada
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Montreal, Quebec, H2V 2K1, Canada
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Montreal, Quebec, H2X 0A9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1S 4L8, Canada
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Québec, Quebec, G1V 4G5, Canada
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Québec, Quebec, G1V 4W2, Canada
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Trois-Rivières, Quebec, G8T 7A1, Canada
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Bengbu, 233004, China
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Chengdu, 610072, China
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Guangzhou, 510120, China
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Hangzhou, 310003, China
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Hangzhou, 310014, China
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Hengyang, 421001, China
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Lanzhou, 730030, China
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Nanchang, 330006, China
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Nanjing, 210009, China
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Qingdao, 266011, China
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Shanghai, 200031, China
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Shanghai, 200433, China
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Suzhou, 215006, China
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Taizhou, 225300, China
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Tianjin, 300121, China
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Tianjin, 300211, China
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Wenzhou, 325027, China
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Wuhan, 430060, China
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Xi'an, 710068, China
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Yinchuan, 750001, China
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Zunyi, 563100, China
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Aalborg, 9000, Denmark
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Aarhus N, 8200, Denmark
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Hillerød, 3400, Denmark
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Hvidovre, 2650, Denmark
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København NV, 2400, Denmark
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Køge, 4600, Denmark
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Odense, 5000, Denmark
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Vejle, 7100, Denmark
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Berlin, 10629, Germany
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Berlin, 13353, Germany
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Dresden, 01307, Germany
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Heidelberg, 69120, Germany
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Lübeck, 23538, Germany
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Marburg, 35043, Germany
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Tübingen, 72076, Germany
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Wiesbaden, 65183, Germany
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Budapest, 1046, Hungary
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Budapest, 1083, Hungary
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Budapest, 1134, Hungary
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Nyíregyháza, 4400, Hungary
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Pécs, 7621, Hungary
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Siófok, 8600, Hungary
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Székesfehérvár, 8000, Hungary
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Bunkyō City, 113-8431, Japan
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Chuo-shi, 409-3898, Japan
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Habikino-shi, 583-0886, Japan
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Ichikawa-shi, 272-0111, Japan
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Itabashi-ku, 173-8610, Japan
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Kashiwa-shi, 277-0882, Japan
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Kisarazu-shi, 292-8535, Japan
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Miyazaki, 880-8510, Japan
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Nagaoka-shi, 940-8621, Japan
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Nerima-ku, 177-0035, Japan
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Niigata, 951-8520, Japan
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Osaka, 553-0003, Japan
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Saitama-shi, 336-8522, Japan
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Sapporo, 003-0022, Japan
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Sendai, 983-8512, Japan
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Suwa-shi, 392-8510, Japan
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Toyonaka Shi, 560-0082, Japan
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Yokohama, 227-8501, Japan
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Yokohama, 236-0037, Japan
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Bialystok, 15-879, Poland
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Bydgoszcz, 85-231, Poland
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Krakow, 31-513, Poland
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Nadarzyn, 05-830, Poland
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Wroclaw, 50-556, Poland
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Wroclaw, 53-301, Poland
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Zawadzkie, 47-120, Poland
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Łodź, 90-153, Poland
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Barakaldo, 48903, Spain
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Barcelona, 08036, Spain
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Jerez de la Frontera, 11407, Spain
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Madrid, 28040, Spain
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Santiago de Compostela, 15706, Spain
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Seville, 41009, Spain
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Dundee, DD1 9SY, United Kingdom
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London, SE1 9RT, United Kingdom
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Manchester, M13 9WL, United Kingdom
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Stockport, SK2 7JE, United Kingdom

Conditions

Explore the condition pages connected to this study.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPS