New drug shows promise in taming debilitating gut diseases

NCT ID NCT05499130

Completed Disease control Sponsor: Teva Branded Pharmaceutical Products R&D, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested an investigational drug, TEV-48574, to see if it could help control two serious inflammatory bowel diseases: Crohn's disease and ulcerative colitis. For 14 weeks, 290 adults with moderate-to-severe disease received one of two doses or a placebo to see which was best at reducing gut inflammation and easing symptoms like pain and diarrhea. The main goals were to see if the drug could bring about remission in ulcerative colitis and improve gut healing in Crohn's disease.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Teva Investigational Site 11257

Winnipeg, Manitoba, R3A 1R9, Canada
Teva Investigational Site 15357

Kissimmee, Florida, 34741, United States
Teva Investigational Site 15358

Liberty, Missouri, 64068, United States
Teva Investigational Site 15359

Pinellas Park, Florida, 33781, United States
Teva Investigational Site 15360

Austin, Texas, 78748, United States
Teva Investigational Site 15361

Tyler, Texas, 75701, United States
Teva Investigational Site 15362

Iowa City, Iowa, 52242, United States
Teva Investigational Site 15363

Columbia, Maryland, 21045, United States
Teva Investigational Site 15364

Salt Lake City, Utah, 84124, United States
Teva Investigational Site 15365

Miami, Florida, 33136, United States
Teva Investigational Site 15366

Katy, Texas, 77494, United States
Teva Investigational Site 15367

Kansas City, Kansas, 66160, United States
Teva Investigational Site 15368

Louisville, Kentucky, 40202, United States
Teva Investigational Site 15369

Las Vegas, Nevada, 89128., United States
Teva Investigational Site 15370

Chapel Hill, North Carolina, 27514, United States
Teva Investigational Site 15371

Dallas, Texas, 75246, United States
Teva Investigational Site 15372

Pearland, Texas, 77584, United States
Teva Investigational Site 15373

St Louis, Missouri, 63110, United States
Teva Investigational Site 15374

San Antonio, Texas, 78229, United States
Teva Investigational Site 15375

Orlando, Florida, 32803, United States
Teva Investigational Site 15556

San Diego, California, 92103, United States
Teva Investigational Site 15557

Greenville, South Carolina, 29607, United States
Teva Investigational Site 15558

North Massapequa, New York, 11758, United States
Teva Investigational Site 15559

Harlingen, Texas, 78550, United States
Teva Investigational Site 15563

Miami, Florida, 33032, United States
Teva Investigational Site 15565

Southlake, Texas, 76092, United States
Teva Investigational Site 15566

Glenview, Illinois, 60026, United States
Teva Investigational Site 15567

Gurnee, Illinois, 60031, United States
Teva Investigational Site 15568

Sun City, Arizona, 85351, United States
Teva Investigational Site 15569

Garland, Texas, 75044, United States
Teva Investigational Site 15573

Cordova, Tennessee, 38018, United States
Teva Investigational Site 15574

New Albany, Indiana, 47150, United States
Teva Investigational Site 15575

Louisville, Kentucky, 40218, United States
Teva Investigational Site 15743

Lubbock, Texas, 79424, United States
Teva Investigational Site 15747

San Diego, California, 92103, United States
Teva Investigational Site 15748

Miami, Florida, 33176, United States
Teva Investigational Site 15750

Beavercreek, Ohio, 45440, United States
Teva Investigational Site 30284

Rozzano, 20089, Italy
Teva Investigational Site 30285

Milan, 20132, Italy
Teva Investigational Site 30286

Milan, 20157, Italy
Teva Investigational Site 30300

San Giovanni Rotondo, 71013, Italy
Teva Investigational Site 30301

Turin, 10128, Italy
Teva Investigational Site 30303

San Donato Milanese, 20097, Italy
Teva Investigational Site 30304

Brescia, 25123, Italy
Teva Investigational Site 31291

Seville, 41009, Spain
Teva Investigational Site 31292

Valencia, 46026, Spain
Teva Investigational Site 31293

Huelva, 21005, Spain
Teva Investigational Site 31301

Las Palmas de Gran Canaria, 35010, Spain
Teva Investigational Site 31302

Córdoba, 14004, Spain
Teva Investigational Site 31318

Santiago de Compostela, 15702, Spain
Teva Investigational Site 31325

Alicante, 03010, Spain
Teva Investigational Site 32793

Kiel, 24105, Germany
Teva Investigational Site 32794

Ulm, 89081, Germany
Teva Investigational Site 32795

Tübingen, 72076, Germany
Teva Investigational Site 32796

Berlin, 10318, Germany
Teva Investigational Site 32797

Leipzig, 04103, Germany
Teva Investigational Site 32872

Berlin, 12559, Germany
Teva Investigational Site 32873

Duisburg, 47055, Germany
Teva Investigational Site 32874

Wipperfürth, 51688, Germany
Teva Investigational Site 33055

Innsbruck, 6020, Austria
Teva Investigational Site 33056

Vienna, 1090, Austria
Teva Investigational Site 34305

London, SE1 9RT, United Kingdom
Teva Investigational Site 35277

Nice, 06200, France
Teva Investigational Site 35279

Saint-Priest-en-Jarez, 42270, France
Teva Investigational Site 35280

Caen, 14000, France
Teva Investigational Site 35295

Nantes, 44300, France
Teva Investigational Site 37133

Liège, 4000, Belgium
Teva Investigational Site 37134

Edegem, 2650, Belgium
Teva Investigational Site 41014

Tromsø, 9038, Norway
Teva Investigational Site 41015

Lorenskog, 1478, Norway
Teva Investigational Site 51333

Székesfehérvár, H-8000, Hungary
Teva Investigational Site 51334

Budapest, 1085, Hungary
Teva Investigational Site 51335

Budapest, H-1033, Hungary
Teva Investigational Site 51336

Gyöngyös, 3200, Hungary
Teva Investigational Site 51338

Vác, H-2600, Hungary
Teva Investigational Site 53508

Szczecin, 71-434, Poland
Teva Investigational Site 53509

Zamość, 22-400, Poland
Teva Investigational Site 53510

Wroclaw, 52-416, Poland
Teva Investigational Site 53511

Łęczna, 21-010, Poland
Teva Investigational Site 53512

Krakow, 31-506, Poland
Teva Investigational Site 53513

Rzeszów, 35-326, Poland
Teva Investigational Site 53514

Lodz, 91-495, Poland
Teva Investigational Site 53515

Lodz, 90-752, Poland
Teva Investigational Site 53516

Poznan, 60-529, Poland
Teva Investigational Site 53517

Poznan, 60-324, Poland
Teva Investigational Site 53518

Nowy Targ, 34-400, Poland
Teva Investigational Site 53519

Szczecin, 71-685, Poland
Teva Investigational Site 53520

Wroclaw, 53-673, Poland
Teva Investigational Site 53542

Częstochowa, 42-202, Poland
Teva Investigational Site 53543

Elblag, 82-300, Poland
Teva Investigational Site 53544

Gdansk, 80-382, Poland
Teva Investigational Site 53545

Gdynia, 81-537, Poland
Teva Investigational Site 53546

Katowice, 40-040, Poland
Teva Investigational Site 53547

Kłodzko, 57-300, Poland
Teva Investigational Site 53548

Krakow, 31-156, Poland
Teva Investigational Site 53549

Poznan, 54-144, Poland
Teva Investigational Site 53550

Sopot, 81-756, Poland
Teva Investigational Site 53551

Staszów, 28-200, Poland
Teva Investigational Site 53552

Tarnów, 33-100, Poland
Teva Investigational Site 53553

Torun, 87-100, Poland
Teva Investigational Site 53554

Wadowice, 34-100, Poland
Teva Investigational Site 53555

Warsaw, 04-501, Poland
Teva Investigational Site 53556

Warsaw, 02-786, Poland
Teva Investigational Site 53557

Warsaw, 00-189, Poland
Teva Investigational Site 53558

Wroclaw, 50-381, Poland
Teva Investigational Site 53559

Opole, 45-819, Poland
Teva Investigational Site 53560

Krakow, 30-363, Poland
Teva Investigational Site 53562

Wroclaw, 53-611, Poland
Teva Investigational Site 53563

Poznan, 54-144, Poland
Teva Investigational Site 53565

Bydgoszcz, 85-794, Poland
Teva Investigational Site 53566

Poznan, 60-702, Poland
Teva Investigational Site 53567

Wroclaw, 53-149, Poland
Teva Investigational Site 53570

Warsaw, 02-672, Poland
Teva Investigational Site 53571

Jelenia Góra, 58-500, Poland
Teva Investigational Site 53572

Piotrkow Trybunalski, 97-300, Poland
Teva Investigational Site 53573

Tarnów, 33-100, Poland
Teva Investigational Site 54220

Slaný, 274 01, Czechia
Teva Investigational Site 54221

Brno, 615 00, Czechia
Teva Investigational Site 54222

Klatovy, 339 01, Czechia
Teva Investigational Site 54241

Prague, 140 00, Czechia
Teva Investigational Site 54242

Zábřeh, 78901, Czechia
Teva Investigational Site 58322

Uzhhorod, 88000, Ukraine
Teva Investigational Site 58323

Uzhhorod, 88000, Ukraine
Teva Investigational Site 58324

Ivano-Frankivsk, 76008, Ukraine
Teva Investigational Site 58325

Lviv, 79010, Ukraine
Teva Investigational Site 58327

Chernivtsi, 58002, Ukraine
Teva Investigational Site 58328

Ternopil, 46002, Ukraine
Teva Investigational Site 58329

Lviv, 79000, Ukraine
Teva Investigational Site 58330

Vinnytsia, 21018, Ukraine
Teva Investigational Site 58331

Vinnytsia, 21018, Ukraine
Teva Investigational Site 58332

Lviv, 79010, Ukraine
Teva Investigational Site 59196

Sofia, 1784, Bulgaria
Teva Investigational Site 59197

Sofia, 1618, Bulgaria
Teva Investigational Site 59198

Pleven, 5803, Bulgaria
Teva Investigational Site 59199

Sofia, 1680, Bulgaria
Teva Investigational Site 59243

Gorna Oryahovitsa, 5100, Bulgaria
Teva Investigational Site 62071

Košice, 040 13, Slovakia
Teva Investigational Site 62072

Šahy, 936 01, Slovakia
Teva Investigational Site 62073

Bratislava, 811 09, Slovakia
Teva Investigational Site 62074

Bardejov, 085 01, Slovakia
Teva Investigational Site 62076

Prešov, 080 01, Slovakia
Teva Investigational Site 62097

Prešov, 080 01, Slovakia
Teva Investigational Site 62098

Banská Bystrica, 975 17, Slovakia
Teva Investigational Site 62099

Rimavská Sobota, 979 01, Slovakia
Teva Investigational Site 80179

Afula, 1834111, Israel
Teva Investigational Site 80180

Rehovot, 7661041, Israel
Teva Investigational Site 80182

Kfar Saba, 4428164, Israel
Teva Investigational Site 80184

Holon, 58100, Israel
Teva Investigational Site 80191

Beersheba, 8410101, Israel
Teva Investigational Site 81052

Tbilisi, 0119, Georgia
Teva Investigational Site 81053

Tbilisi, 0180, Georgia
Teva Investigational Site 81054

Tbilisi, 0160, Georgia
Teva Investigational Site 81055

Tbilisi, 0180, Georgia
Teva Investigational Site 81056

Tbilisi, 0178, Georgia
Teva Investigational Site 81057

Tbilisi, 0102, Georgia
Teva Investigational Site 84110

Kashiwa, 277-0871, Japan
Teva Investigational Site 84111

Toyama, 930-8550, Japan
Teva Investigational Site 84112

Fukuoka, 814-0180, Japan
Teva Investigational Site 84113

Osaka, 530-0011, Japan
Teva Investigational Site 84114

Sakura, 285-8741, Japan
Teva Investigational Site 84115

Mitaka, 181-8611, Japan
Teva Investigational Site 84116

Shinjuku, 169-0073, Japan
Teva Investigational Site 84117

Minato, 108-8642, Japan
Teva Investigational Site 84118

Nagoya, 457-8511, Japan

Conditions

Explore the condition pages connected to this study.

COLITIS, ULCERATIVE CROHN DISEASE