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New drug cocktail aims to shrink lung tumors without chemo

NCT ID NCT06772623

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This study tests a new drug called telisotuzumab adizutecan (ABBV-400) combined with an immunotherapy drug (budigalimab or pembrolizumab) in people with advanced non-squamous lung cancer who have not had prior treatment. The goal is to find the best dose that is safe and effective. About 252 adults will take part at sites worldwide. The trial has two stages: first, finding a safe dose, then comparing two doses of the new combo against standard chemo-immunotherapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Telisotuzumab adizutecan (ABBV-400) combined with budigalimab or pembrolizumab

What this could lead to

If successful, this could provide a new first-line treatment option for people with advanced non-squamous lung cancer who cannot use targeted therapies.

What could go wrong

This is an early-phase trial (1b/2) with a small number of participants, so the combination may not prove more effective or safer than current standard care. Side effects from the drug combination are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON SMALL CELL LUNG CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • AZ-Delta. /ID# 272433

    RECRUITING

    Roeselare, West-Vlaanderen, 8800, Belgium

  • Adana Medical Park Seyhan Hastanesi /ID# 272875

    RECRUITING

    Adana, 01140, Turkey (Türkiye)

  • Aichi Cancer Center /ID# 271978

    RECRUITING

    Nagoya, Aichi-ken, 464-8681, Japan

  • Ankara Universitesi Tip Fakultesi Cebeci Hastanesi /ID# 272873

    RECRUITING

    Ankara, 06620, Turkey (Türkiye)

  • Astera Cancer Care /ID# 271915

    RECRUITING

    East Brunswick, New Jersey, 08816-4096, United States

  • Azienda Ospedaliero Universitaria San Luigi Gonzaga /ID# 268641

    RECRUITING

    Orbassano, Torino, 10043, Italy

  • Azienda Ospedaliero Universitaria delle Marche /ID# 268667

    RECRUITING

    Ancona, 60126, Italy

  • CHU Nantes - Hopital Laennec /ID# 268475

    RECRUITING

    Saint-Herblain, Loire-Atlantique, 44800, France

  • Cancer Hospital - Chinese Academy of Medical Sciences /ID# 269715

    RECRUITING

    Beijing, Beijing Municipality, 100021, China

  • Centre Antoine-Lacassagne /ID# 268486

    RECRUITING

    Nice, Provence-Alpes-Côte d'Azur Region, 06189, France

  • Centre De Cancerologie Du Grand Montpellier /ID# 273724

    RECRUITING

    Montpellier, Occitanie, 34070, France

  • Changhua Christian Hospital /ID# 280139

    RECRUITING

    Changhua, 500, Taiwan

  • Community Health Network /ID# 273437

    COMPLETED

    Indianapolis, Indiana, 46202, United States

  • Complejo Hospitalario Universitario A Coruña /ID# 271456

    RECRUITING

    A Coruña, A Coruna, 15006, Spain

  • Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation /ID# 268789

    RECRUITING

    Chiayi City, 62247, Taiwan

  • Dana-Farber Cancer Institute /ID# 278417

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • FOMAT Medical Research - Clinica mi Salud by Focil Med /ID# 274450

    RECRUITING

    Oxnard, California, 93030, United States

  • First Affiliated Hospital of Shanxi Medical University /ID# 276482

    RECRUITING

    Taiyuan, Shanxi, 030001, China

  • Fujian Province Cancer Hospital /ID# 269150

    RECRUITING

    Fuzhou, Fujian, 350014, China

  • Groupe Sante CHC - Clinique du MontLegia /ID# 271760

    RECRUITING

    Liège, Liege, 4000, Belgium

  • Hamatologie-Onkologie im Zentrum MVZ GmbH /ID# 273043

    RECRUITING

    Augsburg, Bavaria, 86150, Germany

  • Hirosaki University Hospital /ID# 274410

    RECRUITING

    Hirosaki, Aomori, 036-8563, Japan

  • Hope And Healing Cancer Services /ID# 276223

    RECRUITING

    Hinsdale, Illinois, 60521, United States

    Contact Phone: •••-•••-••••

  • Hospital Clinic de Barcelona /ID# 271452

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital General Universitario de Alicante Doctor Balmis /ID# 271316

    RECRUITING

    Alicante, 03010, Spain

  • Hospital Santa Creu i Sant Pau /ID# 271311

    RECRUITING

    Barcelona, 08041, Spain

  • Hospital Universitario Marques de Valdecilla /ID# 271314

    RECRUITING

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Virgen Macarena /ID# 271447

    RECRUITING

    Seville, Sevilla, 41009, Spain

  • Hospital Universitario Virgen de la Victoria /ID# 271312

    RECRUITING

    Málaga, 29010, Spain

  • Hunan Province Cancer Hospital /ID# 269679

    RECRUITING

    Changsha, Hunan, 410013, China

  • Huntsman Cancer Institute /ID# 271686

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 268675

    RECRUITING

    Bologna, 40138, Italy

  • IRCCS Istituti Fisioterapici Ospitalieri-Istituto Nazionale Tumori Regina Elena /ID# 268626

    RECRUITING

    Rome, Roma, 00144, Italy

  • Institut Curie /ID# 271395

    RECRUITING

    Paris, Île-de-France Region, 75248, France

  • Institut Gustave Roussy /ID# 258373

    RECRUITING

    Villejuif, Val-de-Marne, 94805, France

  • Institut de Cancerologie de l'Ouest Rene Gauducheau /ID# 268484

    RECRUITING

    Saint-Herblain, Loire-Atlantique, 44805, France

  • Istituto Europeo Di Oncologia /Id# 268670

    RECRUITING

    Milan, Milano, 20121, Italy

  • Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST - IRCCS /ID# 268684

    RECRUITING

    Meldola, Forlì-Cesena, 47014, Italy

  • Jessa Ziekenhuis - Campus Virga Jesse /ID# 268573

    RECRUITING

    Hasselt, Limburg, 3500, Belgium

  • Joe Arrington Cancer Research /ID# 272776

    RECRUITING

    Lubbock, Texas, 79410-1121, United States

  • Kansas City Cancer Center /ID# 273679

    RECRUITING

    Overland Park, Kansas, 66210, United States

  • Kaohsiung Chang Gung Memorial Hospital /ID# 268138

    RECRUITING

    Kaohsiung City, 833, Taiwan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 268139

    RECRUITING

    Kaohsiung City, 807, Taiwan

  • Kyoto University Hospital /ID# 272312

    RECRUITING

    Kyoto, Kyoto, 606-8507, Japan

  • Leicester Royal Infirmary /ID# 276035

    RECRUITING

    Leicester, Leicestershire, LE1 5WW, United Kingdom

  • Linkou Chang Gung Memorial Hospital /ID# 268137

    RECRUITING

    Taoyuan City, 333, Taiwan

  • Liuzhou People's hospital /ID# 269667

    RECRUITING

    Liuzhou, Guangxi, 545006, China

  • Lungenklinik Hemer /ID# 269779

    RECRUITING

    Hemer, North Rhine-Westphalia, 58675, Germany

  • Mayo Clinic Hospital - Phoenix /ID# 272971

    ACTIVE_NOT_RECRUITING

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic Hospital Jacksonville /ID# 275073

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic-Rochester /ID# 274512

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Mid Florida Hematology And Oncology Center /ID# 273777

    RECRUITING

    Orange City, Florida, 32763, United States

  • Millennium Physicians /ID# 271717

    COMPLETED

    Houston, Texas, 77090, United States

  • NHO Nagoya Medical Center /ID# 272515

    RECRUITING

    Nagoya, Aichi-ken, 460-0001, Japan

  • Nagasaki University Hospital /ID# 273310

    RECRUITING

    Nagasaki, 852-8501, Japan

  • Nanjing Drum Tower Hospital /ID# 269762

    RECRUITING

    Nanjing, Jiangsu, 210008, China

  • National Cancer Center Hospital /ID# 273192

    RECRUITING

    Chuo-Ku, Tokyo, 104-0045, Japan

  • National Taiwan University Cancer Center (Ntucc) /ID# 271586

    RECRUITING

    Taipei, 106, Taiwan

  • Necmettin Erbakan Universitesi Meram Tip Fakultesi - Eski Hastane /ID# 272882

    RECRUITING

    Konya, 42080, Turkey (Türkiye)

  • New York Cancer And Blood Specialists - Shirley /ID# 272547

    RECRUITING

    Shirley, New York, 11967, United States

  • Niigata University Medical and Dental Hospital /ID# 274448

    RECRUITING

    Niigata, Niigata, 951-8520, Japan

  • Northwest Medical Specialties Tacoma /ID# 270469

    RECRUITING

    Tacoma, Washington, 98405, United States

  • Ondokuz Mayis Universitesi /ID# 272899

    RECRUITING

    Samsun, 55139, Turkey (Türkiye)

  • Osaka Medical And Pharmaceutical University Hospital /ID# 273309

    RECRUITING

    Takatsuki, Osaka, 569-8686, Japan

  • Pamukkale Universitesi /ID# 272893

    RECRUITING

    Denizli, 20070, Turkey (Türkiye)

  • Pan American Center for Oncology Trials - Rio Piedras /ID# 268827

    RECRUITING

    Rio Piedras, 00935, Puerto Rico

  • Parc de Salut Mar - Hospital del Mar /ID# 271310

    RECRUITING

    Barcelona, 08003, Spain

  • Parkview Comprehensive Cancer Center /ID# 271879

    RECRUITING

    Fort Wayne, Indiana, 46845, United States

  • Providence - St. Jude Medical Center /ID# 271414

    RECRUITING

    Fullerton, California, 92835, United States

  • Rocky Mountain Cancer Centers - Lone Tree /ID# 272603

    RECRUITING

    Lone Tree, Colorado, 80124, United States

  • Sakarya Egitim ve Arastirma Hastanesi /ID# 272878

    RECRUITING

    Adapazarı, Sakarya, 54290, Turkey (Türkiye)

  • Shanghai Chest Hospital /ID# 269155

    RECRUITING

    Shanghai, Shanghai Municipality, 200030, China

  • Shanghai Pulmonary Hospital /ID# 276397

    RECRUITING

    Shanghai, Shanghai Municipality, 200433, China

  • Sichuan Cancer Hospital /ID# 269712

    RECRUITING

    Chengdu, Sichuan, 610041, China

  • Slk-Kliniken Heilbronn /ID# 269621

    RECRUITING

    Heilbronn, Baden-Wurttemberg, 74078, Germany

  • Spoknwrd Clinical Trials /ID# 273776

    RECRUITING

    Easton, Pennsylvania, 18045, United States

    Contact Phone: •••-•••-••••

  • St. Luke'S /ID# 273344

    RECRUITING

    Duluth, Minnesota, 55805, United States

  • Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 274549

    RECRUITING

    Kielce, Świętokrzyskie Voivodeship, 25-734, Poland

  • Taipei Veterans General Hospital /ID# 268787

    RECRUITING

    Taipei, 112, Taiwan

  • The Cancer Institute Hospital Of JFCR /ID# 271989

    RECRUITING

    Koto-ku, Tokyo, 135-8550, Japan

  • The First Affiliated Hospital of Nanchang University /ID# 269190

    RECRUITING

    Nanchang, Jiangxi, 330006, China

  • The First Affiliated Hospital of Xi'an Jiaotong University /ID# 271904

    RECRUITING

    Xi'an, Shaanxi, 710061, China

  • The Mark H Zangmeister Center /ID# 272502

    RECRUITING

    Columbus, Ohio, 43219, United States

  • Tri-Service General Hospital /ID# 269211

    RECRUITING

    Taipei, 114, Taiwan

  • UCLA - Santa Monica /ID# 271690

    RECRUITING

    Santa Monica, California, 90404, United States

  • Union Hospital - Tongji Medical College /ID# 272286

    RECRUITING

    Wuhan, Hubei, 430022, China

  • Universitaetsklinikum Frankfurt /ID# 268721

    RECRUITING

    Frankfurt am Main, Hesse, 60590, Germany

  • Universitaetsklinikum Freiburg /ID# 268473

    RECRUITING

    Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany

  • Universitaetsklinikum Koeln /ID# 268489

    RECRUITING

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Universitaetsklinikum Wuerzburg /ID# 275445

    RECRUITING

    Würzburg, Bavaria, 97080, Germany

  • University Hospitals Cleveland Medical Center /ID# 271726

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • University Of Colorado - Anschutz Medical Campus /ID# 269069

    RECRUITING

    Aurora, Colorado, 80045, United States

  • Universitätsklinikum Jena /ID# 269700

    RECRUITING

    Jena, Thuringia, 07747, Germany

  • Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie /ID# 273170

    RECRUITING

    Lublin, Lublin Voivodeship, 20-090, Poland

  • Uniwersytecki Szpital Kliniczny w Bialymstoku /ID# 276848

    RECRUITING

    Bialystok, Podlaskie Voivodeship, 15-540, Poland

  • Uniwersyteckie Centrum Kliniczne /ID# 272418

    RECRUITING

    Gdansk, Pomeranian Voivodeship, 80-214, Poland

  • Velindre Cancer Centre /ID# 271840

    RECRUITING

    Cardiff, CF14 2TL, United Kingdom

  • Virgnia Cancer Specialists /ID# 269633

    RECRUITING

    Leesburg, Virginia, 20176, United States

  • Vista Oncology - East Olympia /ID# 275438

    RECRUITING

    Olympia, Washington, 98506, United States

  • West China Hospital of Sichuan University /ID# 270244

    RECRUITING

    Chengdu, Sichuan, 610041, China

  • Yokohama Municipal Citizen's Hospital /ID# 271979

    RECRUITING

    Yokohama, Kanagawa, 221-0855, Japan

  • Yunnan Province Cancer Hospital /ID# 272331

    RECRUITING

    Kunming, Yunnan, 650106, China

  • ohO Research GmbH /ID# 273060

    RECRUITING

    Oldenburg in Holstein, Schleswig-Holstein, 23758, Germany