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Can a gentle brain current boost memory training in early dementia?

NCT ID NCT06559254

Symptom relief Sponsor: Hospital Authority, Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Researchers are testing whether a mild electrical current applied to the scalp can improve the effects of cognitive training in older adults with mild major neurocognitive disorder. Participants receive either active or sham brain stimulation while doing computer-based memory exercises for two weeks. The study measures changes in memory and thinking tasks right after the sessions and four weeks later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation, a non-invasive brain stimulation technique
What this could lead to
If it works, pairing brain stimulation with cognitive training could become a way to help people with mild dementia think more clearly for longer.
What could go wrong
The trial is small, with 36 participants, and the benefits of cognitive training alone tend to be modest and short-lived. Brain stimulation may add little, and any gains might fade after the sessions end.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Sep 2024

Finished

Sep 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 65 years of age or above * Right-handedness Chinese as defined by Edinburgh handedness inventory * Cantonese speaking * Fulfil the criteria of Major neurocognitive disorder, as defined by the 5 th Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM- 5) * Clinical Dementia Rating Global score = 1 Exclusion Criteria: * Active diagnosis of mood disorder or psychosis * Alcohol or substance dependence * Initiation or change in dose of cognitive enhancer within 6 months prior to the onset of the study 14 * Poor physical condition and mobility * Having regular cognitive training (as defined by at least three 1-hour weekly structured and standardized cognitive training in recent 3 months) 15 * Receiving tDCS within 2 months prior to the onset of study 16 * Significant communication or visual impairment * Having metal implant in area above upper back, or having metal crown or metal brace, or pacemaker

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major neurocognitive disorder

Contacts and locations

Locations

  • Queen Mary Hospital

    Hong Kong, Hong Kong

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