Breakthrough trial tests Life-Saving TB treatment for most vulnerable HIV patients
NCT ID NCT04738812
First seen Jan 07, 2026 · Last updated Apr 21, 2026 · Updated 12 times
Summary
This large study tested whether a stronger, intensified tuberculosis (TB) treatment regimen could save more lives than standard treatment in HIV patients hospitalized with TB who have very low immune cell counts. Over 1,300 participants received either the intensified treatment (with higher drug doses plus additional medications) or standard WHO-recommended treatment for 8 weeks, followed by identical continuation treatment. Researchers tracked deaths and safety over 48 weeks to see which approach worked better for this high-risk group.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ignace Deen Hospital
Conakry, Guinea
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Jamot Hospital
Yaoundé, Cameroon
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MACHAVA Hospital
Maputo, Mozambique
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Mbarara Regional Referral hospital
Mbarara, Uganda
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National Center for HIV/AIDS, Dermatology and STD (NCHADS)
Phnom Penh, Cambodia
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University Teaching Hospital
Lusaka, Zambia
Conditions
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