New drug cocktail targets childhood cancers with missing proteins
NCT ID NCT05407441
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a combination of three drugs—tazemetostat, nivolumab, and ipilimumab—in children with rare tumors that lack the INI1 or SMARCA4 proteins. The goal is to find a safe dose and see if the drugs can shrink tumors. About 49 children with specific tumor types are being enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tazemetostat, nivolumab, and ipilimumab
- What this could lead to
- If this works, it could offer a new treatment option for children with rare, hard-to-treat tumors that lack certain proteins.
- What could go wrong
- This is an early-phase trial with only 49 participants, so results may not apply broadly. The drug combination can cause serious side effects, and it's not yet known if it will shrink tumors effectively.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
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