Withdrawn study sought to stop brain 'Storms' after blood clot surgery

NCT ID NCT04966546

Terminated Knowledge-focused Sponsor: University of New Mexico Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study planned to test whether the drug memantine could reduce harmful brain waves called spreading depolarizations after surgery for chronic subdural hematoma, a common condition in older adults where fluid compresses the brain. The trial was withdrawn before any participants were enrolled, so no data was collected. The goal was to see if blocking these brain waves could prevent post-surgery confusion or weakness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Memantine Hydrochloride
What this could lead to: If it had worked, this could point toward a treatment to reduce confusion or weakness after brain surgery for chronic subdural hematoma.
What could go wrong: The trial was withdrawn before enrolling anyone, so no results exist. It was a very early feasibility study, and memantine's effect on these brain waves was unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hematoma, Subdural, Chronic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC SUBDURAL HEMATOMA

Contacts and locations

Locations

University of New Mexico

Albuquerque, New Mexico, 87131, United States

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