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Nerve block after C-Section may speed healing and lower stress

NCT ID NCT05840406

Symptom relief Sponsor: University Hospital Sestre Milosrdnice Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding a TAP block (a type of nerve block) to standard pain relief after a cesarean section could improve wound healing and reduce stress on the body. 105 women having planned C-sections were randomly assigned to receive either standard pain medication alone, or standard medication plus a TAP block with levobupivacaine, or a TAP block with levobupivacaine and dexmedetomidine. Researchers measured wound healing, stress hormones, and immune markers in the days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
levobupivacaine and dexmedetomidine
What this could lead to
If it works, this could lead to better pain control and faster wound healing after cesarean delivery.
What could go wrong
This is a small, completed study with no phase designation, so results may not apply broadly. The benefits over standard pain management may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

105 people

The number who actually took part.

Started

Sep 2024

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for the elective cesarean section through Pfannenstiel incision under spinal anesthesia * Age \>18 * American Society of Anesthesiologists (ASA) physical status II * Body mass index \< 40 mg/kg² * \>35 gestational weeks Exclusion Criteria: * participant's refusal to participate in the study * ASA physical status \>II * emergency cesarean section * twin or triplets pregnancy * history of allergy to the local anesthetic or any other drug used in this study (dexmedetomidine, acetaminophen, tramadol, nonsteroidal anti-inflammatory drugs) * contraindications for spinal anesthesia or TAP block Drop out from the study: * the change in anesthetic technique from spinal to the general anesthesia * the need for the blood transfusion * acute mastitis, puerperal endometritis, and/or wound infection developed in the first 72 hours postoperatively * failed TAP block

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cesarean section Postoperative pain Wound heal

Contacts and locations

Locations

  • University Hospital Center Sestre milosrdnice

    Zagreb, 10000, Croatia

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