Promising new combo therapies aim to control multiple myeloma

NCT ID NCT06208150

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This phase 3 study compares two new drug combinations (talquetamab plus pomalidomide or talquetamab plus teclistamab) against standard treatments for multiple myeloma, a blood cancer. About 795 participants will be randomly assigned to one of the groups. The goal is to see which combination better delays cancer progression and improves response rates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • 251 Airforces Hospital

    Athens, 115 25, Greece

  • A O U Sant Orsola Malpighi

    Bologna, 40138, Italy

  • ARNAS Garibaldi P O Nesima

    Catania, 95122, Italy

  • AZ Nikolaas - Campus Sint-Niklaas Moerland

    Sint-Niklaas, 9100, Belgium

  • Aarhus University Hospital

    Aarhus, 8200, Denmark

  • Akademiska Sjukhuset

    Uppsala, 75185, Sweden

  • Alexandra General Hospital of Athens

    Athens, 115 28, Greece

  • Ankara Universitesi Tip Fakultesi Cebeci Arastirma ve Uygulama Hastanesi

    Ankara, 06620, Turkey (Türkiye)

  • Arthur J E Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2, Canada

  • Asst Ovest Milanese - Ospedale Di Legnano

    Legnano, 20025, Italy

  • Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria

    Alessandria, 15121, Italy

  • Azienda Ospedaliera Universitaria Integrata Verona

    Verona, 37134, Italy

  • Beijing Chaoyang Hospital

    Beijing, 100020, China

  • Blackpool Victoria Hospital

    Blackpool, FY3 8NR, United Kingdom

  • Bon Secours Saint Francis Cancer Center

    Greenville, South Carolina, 29607, United States

  • Box Hill Hospital

    Box Hill, 3128, Australia

  • British Columbia Cancer Agency

    Vancouver, British Columbia, V5Z4E6, Canada

  • CHRU Tours Hopital Bretonneau

    Tours, 37044, France

  • CHU Nantes

    Nantes, 44093, France

  • CHU de Bordeaux - Hospital Haut-Leveque

    Pessac, 33604, France

  • CHU de Limoges Hopital Dupuytren

    Limoges, 87042, France

  • CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont

    Montreal, Quebec, H1T 2M4, Canada

  • Carmel Medical Center

    Haifa, 3436212, Israel

  • Catharinaziekenhuis

    Eindhoven, 5623 EJ, Netherlands

  • Centro de Quimioterapia e Investigacion

    Guadalajara, 45645, Mexico

  • Centrum Onkologii Ziemii Lubelskiej

    Lublin, 20-090, Poland

  • Cetus Oncologia

    Belo Horizonte, 30110-022, Brazil

  • Changzhou No 2 Peoples Hospital

    Changzhou, 213000, China

  • Chonnam National University Hwasun Hospital

    Jeollanam-do, 58128, South Korea

  • City of Hope Cancer Center

    Newnan, Georgia, 30265, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Clinica Medica Sao Germano S/S LTDA

    São Paulo, 04537-081, Brazil

  • Clinica Univ. de Navarra

    Pamplona, 31008, Spain

  • Complejo Hosp de Navarra - Hosp de Navarra

    Pamplona, 31008, Spain

  • DF Star

    Brasília, 70390-140, Brazil

  • Dartmouth Hitchcock Medical Center

    Lebanon, New Hampshire, 03756, United States

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032, Hungary

  • Deenanath Mangeshkar Hospital and Research Centre

    Pune, 411004, India

  • Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely

    Budapest, 1097, Hungary

  • Dong-A University Hospital

    Busan, 49201, South Korea

  • Duke University Medical Center

    Durham, North Carolina, 27705, United States

  • Fakultni Nemocnice Ostrava

    Ostrava, 708 52, Czechia

  • Fakultni nemocnice Brno

    Brno-Bohunice, 625 00, Czechia

  • Fakultni nemocnice Hradec Kralove

    Hradec Králové, 500 05, Czechia

  • First hospital affiliated of Zhejiang Medical university

    Hangzhou, 310003, China

  • Flevoziekenhuis

    Almere Stad, 1315RA, Netherlands

  • Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano

    Milan, 20122, Italy

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100, Italy

  • Fortis Memorial Research Institute

    Gurgaon, 122002, India

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington, 98109, United States

  • Fujian Meidical University Union Hospital

    Fuzhou, 350001, China

  • Fukuoka University Hospital

    Fukuoka, 814-0180, Japan

  • Fundacao Antonio Prudente A C Camargo Cancer Center

    São Paulo, 01509 900, Brazil

  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base

    São José do Rio Preto, 15090 000, Brazil

  • Fundacao Universidade de Caxias do Sul

    Caxias do Sul, 95070 560, Brazil

  • Fundaleu

    Buenos Aires, C1114AAN, Argentina

  • Gabrail Cancer Center

    Canton, Ohio, 44718, United States

  • Ghent University Hospital

    Ghent, 9000, Belgium

  • Gold Coast University Hospital

    Southport, 4215, Australia

  • Grand Hopital De Charleroi Site Les Viviers

    Charleroi, 6060, Belgium

  • Gundersen Health System

    La Crosse, Wisconsin, 54601, United States

  • Haga ziekenhuis

    The Hague, 2545 CH, Netherlands

  • Hamamatsu University Hospital

    Hamamatsu, 431 3192, Japan

  • Hematologica Alta Especialidad

    Huixquilucan, 52787, Mexico

  • Henry Ford Cancer Institute

    Detroit, Michigan, 48202, United States

  • Henry Ford Health Providence Southfield Hospital

    Southfield, Michigan, 48075, United States

  • Hopital Claude Huriez

    Lille, 59000, France

  • Hopital Saint Louis

    Paris, 75010, France

  • Hosp Clinico Univ de Salamanca

    Salamanca, 37007, Spain

  • Hosp Univ Vall D Hebron

    Barcelona, 08035, Spain

  • Hosp. Clinico Univ. de Santiago

    Santiago de Compostela, 15706, Spain

  • Hosp. San Pedro de Alcantara

    Cáceres, 10003, Spain

  • Hosp. Univ. Donostia

    Donostia / San Sebastian, 20014, Spain

  • Hosp. Univ. La Paz

    Madrid, 28046, Spain

  • Hosp. Univ. Lucus Augusti

    Lugo, 27003, Spain

  • Hosp. Univ. Marques de Valdecilla

    Santander, 39008, Spain

  • Hosp. Univ. Son Espases

    Palma de Mallorca, 07120, Spain

  • Hosp. Univ. Virgen de Las Nieves

    Granada, 18014, Spain

  • Hosp. Univ. de Burgos

    Burgos, 09003, Spain

  • Hosp. de Cabuenes

    Asturias, 33394, Spain

  • Hospices Civils de Lyon HCL

    Lyon, 69002, France

  • Hospital Aleman

    CABA, C1118AAT, Argentina

  • Hospital Britanico de Buenos Aires

    Buenos Aires, C1280AEB, Argentina

  • Hospital De Clinicas De Porto Alegre

    Porto Alegre, 90035-903, Brazil

  • Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer

    Curitiba, 81520-060, Brazil

  • Hospital Sao Rafael

    Salvador, 41253 190, Brazil

  • Hospital Universitario Dr Jose Eleuterio Gonzalez

    Monterrey, 64460, Mexico

  • Houston Methodist Neal Cancer Center at Texas Medical Center

    Houston, Texas, 77030, United States

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • Hyogo Medical University Hospital

    Nishinomiya Shi, 663 8501, Japan

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • Institut Paoli Calmettes

    Marseille, 13009, France

  • Institut Universitaire du Cancer Toulouse Oncopole

    Toulouse, 31100, France

  • Institut de Cancerologie Strasbourg Europe ICANS

    Strasbourg, 67200, France

  • Instituto D Or de Pesquisa e Ensino

    São Paulo, 04543 000, Brazil

  • Instituto D Or de Pesquisa e Ensino IDOR

    Recife, 50070-480, Brazil

  • Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)

    Rio de Janeiro, 22793-080, Brazil

  • Isala Kliniek

    Zwolle, 8025 AB, Netherlands

  • Iwate Medical University Hospital

    Shiwa-gun, 028-3695, Japan

  • Japanese Red Cross Medical Center

    Shibuya-ku, 150-8935, Japan

  • Japanese Red Cross Narita Hospital

    Narita, 286-8523, Japan

  • Japanese Red Cross Osaka Hospital

    Osaka, 543-8555, Japan

  • John Theurer Cancer Center at Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Juntendo University Hospital

    Bunkyō City, 113 8431, Japan

  • Juravinski Cancer Centre

    Hamilton, Ontario, L8V5C2, Canada

  • Kanagawa Cancer Center

    Yokohama, 241 8515, Japan

  • Kanazawa University Hospital

    Kanazawa, 920 8641, Japan

  • King Abdullah International Medical Research Center (KAIMRC)

    Riyadh, 11481, Saudi Arabia

  • King Fahad Medical City

    Riyadh, 12231, Saudi Arabia

  • King Faisal Specialist Hospital & Research Center

    Riyadh, 11564, Saudi Arabia

  • Kings College Hospital

    London, SE5 9RS, United Kingdom

  • Klinik Ottakring

    Vienna, 1160, Austria

  • Klinikum Augsburg

    Augsburg, 86156, Germany

  • Klinikum rechts der Isar der TU Muenchen

    München, 81675, Germany

  • Kootenai Health

    Coeur d'Alene, Idaho, 83814, United States

  • LKH - Universitätsklinikum der PMU Salzburg

    Salzburg, 05020, Austria

  • Liv Hospital Ankara

    Ankara, 06680, Turkey (Türkiye)

  • Louis Stokes Cleveland VA Med Ctr

    Cleveland, Ohio, 44106, United States

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • Luminis Health Center for Cancer and Blood Disorders

    Annapolis, Maryland, 21401, United States

  • Mayo Clinic Rochester

    Rochester, Minnesota, 55905, United States

  • Medical College Of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Medical Oncology Hematology Consultants, PA

    Newark, Delaware, 19713, United States

  • Medical University Vienna MUV

    Vienna, A-1090, Austria

  • Medical University of South Carolina

    Charleston, South Carolina, 29425-8900, United States

  • Medipol University Hospital

    Istanbul, 34214, Turkey (Türkiye)

  • Memorial Healthcare System

    Hollywood, Florida, 33021, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Nanfang Hospital of Southern Medical Hospital

    Guangzhou, 510515, China

  • Nanjing Drum Tower Hospital

    Nanjing, 210008, China

  • National Hospital Organization Nagasaki Medical Center

    Nagasaki, 856-8562, Japan

  • Niigata Cancer Center Hospital

    Niigata, 951-8566, Japan

  • Ninewells Hospital

    Dundee, DD1 9SY, United Kingdom

  • Norrlands Universitetssjukhus

    Umeå, 901 85, Sweden

  • NorthWest Medical Specialties, PLLC

    Tacoma, Washington, 98405, United States

  • Norton Cancer Institute

    Louisville, Kentucky, 40207, United States

  • Nottingham City Hospital

    Nottingham, NG5 1PB, United Kingdom

  • Nova Scotia Health Authority

    Halifax, Nova Scotia, B3H 1V7, Canada

  • Odense University Hospital

    Odense C, 5000, Denmark

  • Oncologia Medica-Città Della Salute E Della Scienza Di Torino

    Torino, 10126, Italy

  • Ondokuz Mayis Universitesi Saglik Uygulama ve Arastirma Merkezi

    Samsun, 55200, Turkey (Türkiye)

  • Oregon Health And Science University

    Portland, Oregon, 97239, United States

  • Ospedale Policlinico San Martino IRCCS

    Genova, 16132, Italy

  • Ospedale S. Maria Delle Croci

    Ravenna, 48121, Italy

  • Our Lady of the Lake Hospital

    Baton Rouge, Louisiana, 70808, United States

  • Pamukkale Universitesi Tip Fakultesi

    Denizli, 20070, Turkey (Türkiye)

  • Pecsi Tudomanyegyetem Klinikai Kozpont

    Pécs, 7624, Hungary

  • Peking University First Hospital

    Beijing, 100034, China

  • Peking University People's Hospital

    Beijing, 101199, China

  • Peking University Shenzhen Hospital

    Shenzhen, 518036, China

  • Penn State Milton S Hershey Medical Ctr

    Hershey, Pennsylvania, 17033, United States

  • Perth Blood Institute

    West Perth, 6005, Australia

  • Presidio Ospedaliero Pescara

    Pescara, 65124, Italy

  • Princess Margaret Cancer Centre University Health Network

    Toronto, Ontario, M5G2M9, Canada

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • Qilu Hospital of Shandong University

    Jinan, 250012, China

  • Queen Alexandra Hospital

    Portsmouth, PO6 3LY, United Kingdom

  • Rabin Medical center - Petah-Tikva

    Petah Tikva, 49100, Israel

  • Real e Benemerita Associacao Portuguesa de Beneficencia

    São Paulo, 01323 001, Brazil

  • Regions Hospital

    Saint Paul, Minnesota, 55101, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Royal Adelaide Hospital

    Adelaide, 5000, Australia

  • Ruijing Hospital Affiliated To Shanghai Jiaotong University School Of Medicine

    Shanghai, 200025, China

  • SUNY Upstate Medical University

    Syracuse, New York, 13210, United States

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sanjay Gandhi Postgraduate Institute of Medical Sciences

    Lucknow, 226014, India

  • Sapporo City General Hospital

    Sapporo, 060-8604, Japan

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, S7N 4H4, Canada

  • Semmelweis Egyetem, Belgyogyaszati es Hematologiai Klinika

    Budapest, 1088, Hungary

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Shamir Medical Center Assaf Harofeh

    Be’er Ya‘aqov, 70300, Israel

  • Shanghai Fourth People s Hospital

    Shanghai, 200434, China

  • Shanxi Bethune Hospital

    Taiyuan, 030032, China

  • Sheba Medical Center

    Ramat Gan, 52621, Israel

  • Shengjing Hospital Of China Medical University

    Shenyang, 110055, China

  • Shizuoka Cancer Center

    Sunto Gun, 411 8777, Japan

  • Sichuan Provincial Peoples Hospital

    Chengdu, 610032, China

  • Skanes universitetssjukhus

    Lund, 221 85, Sweden

  • St James University Hospital

    Leeds, LS9 7TF, United Kingdom

  • St Vincents Hospital

    Darlinghurst, 2010, Australia

  • St Vincents Hospital Melbourne

    Fitzroy, 3065, Australia

  • St. Antonius Ziekenhuis Nieuwegein

    Nieuwegein, 3435 CM, Netherlands

  • Sun Yat Sen University Cancer Center

    Guangzhou, 510060, China

  • Swedish Cancer Institute

    Seattle, Washington, 98104, United States

  • Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach

    Kielce, 25 734, Poland

  • Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz

    Nyíregyháza, 4400, Hungary

  • Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza

    Brzozów, 36-200, Poland

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 64239, Israel

  • The Affiliated Hospital of Inner Mongolia Medical College

    Hohhot, 010051, China

  • The Cancer Institute Hospital of JFCR

    Tokyo, 135 8550, Japan

  • The Catholic University of Korea Seoul St Mary s Hospital

    Seoul, 06591, South Korea

  • The First Affiliated Hospital of Fujian Medical University

    Fuzhou, 350005, China

  • The First Affiliated Hospital of Guangxi Medical University

    Nanning, 530021, China

  • The First Affiliated Hospital of NanChang University

    Nanchang, 330006, China

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, 325000, China

  • The Second Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, 710004, China

  • The Second Affiliated Hospital of Zhejiang University College of Medicine

    Hangzhou, 310009, China

  • The Second Xiangya Hospital of Central South Hospital

    Changsha, 410011, China

  • The Sidney Kimmel Comprehensive Cancer Center at John Hopkins

    Baltimore, Maryland, 21287, United States

  • The University of Osaka Hospital

    Suita, 565 0871, Japan

  • The first affiliated hospital of xiamen university

    Xiamen, 361026, China

  • Theageneio Cancer Hospital

    Thessaloniki, 546 39, Greece

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, 19107 4215, United States

  • Tianjin Medical University Cancer Institute and Hospital

    Tianjin, 30060, China

  • Tohoku University Hospital

    Sendai, 980 8574, Japan

  • Tongji Hospital of Tongji University

    Shanghai, 200065, China

  • Tongji Hospital, Tongji Medical College of HUST

    Wuhan, 430030, China

  • Tottori University Hospital

    Tottori, 683-0824, Japan

  • UCLA

    Santa Monica, California, 90404, United States

  • UCSF Fresno

    Clovis, California, 93611, United States

  • UT Southwestern

    Dallas, Texas, 75390, United States

  • UT Southwestern Parkland Hospital

    Dallas, Texas, 75390, United States

  • Ulsan University Hospital

    Ulsan, 44033, South Korea

  • Universitaetsklinikum Halle Saale

    Halle, 06120, Germany

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitaetsklinikum Magdeburg A.oe.R

    Magdeburg, 39120, Germany

  • Universitaetsklinikum Tuebingen

    Tübingen, 72076, Germany

  • Universitaetsklinikum Wuerzburg

    Würzburg, 97080, Germany

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, 602-8566, Japan

  • University Hospital Olomouc

    Olomouc, 779 00, Czechia

  • University Hospital of Wales

    Cardiff, CF14 4HY, United Kingdom

  • University Hospitals Plymouth NHS Trust

    Plymouth, PL6 8DH, United Kingdom

  • University Of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • University Of Pittsburgh Medical Center UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Iowa Health Care

    Waukee, Iowa, 50263, United States

  • University of Maryland School of Medicine

    Baltimore, Maryland, 21201, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Nebraska

    Omaha, Nebraska, 68105, United States

  • University of Tsukuba Hospital

    Tsukuba, 305 8576, Japan

  • University of Virginia

    Charlottesville, Virginia, 22903, United States

  • Uniwersytecki Szpital Kliniczny Nr 1 PUM im prof Tadeusza Sokolowskiego w Szczecinie

    Szczecin, 71-252, Poland

  • Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu

    Wroclaw, 50 367, Poland

  • Varberg Hospital

    Varberg, 432 81, Sweden

  • Vejle Hospital

    Vejle, 7100, Denmark

  • Weill Cornell Medical College

    New York, New York, 10065, United States

  • West Penn Hospital

    Pittsburgh, Pennsylvania, 15224, United States

  • Winship Cancer Institute Emory University

    Atlanta, Georgia, 30322, United States

  • Wojewodzki Szpital Specjalistyczny

    Biała Podlaska, 21 500, Poland

  • Wollongong Hospital

    Wollongong, 2500, Australia

  • Yale University School Of Medicine

    New Haven, Connecticut, 06519, United States

  • Ziekenhuis Oost-Limburg

    Genk, 3600, Belgium

  • oncologia medica - Oncology

    Brindisi, 72100, Italy

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