Promising new combo therapies aim to control multiple myeloma
NCT ID NCT06208150
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times
Summary
This phase 3 study compares two new drug combinations (talquetamab plus pomalidomide or talquetamab plus teclistamab) against standard treatments for multiple myeloma, a blood cancer. About 795 participants will be randomly assigned to one of the groups. The goal is to see which combination better delays cancer progression and improves response rates.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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251 Airforces Hospital
Athens, 115 25, Greece
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A O U Sant Orsola Malpighi
Bologna, 40138, Italy
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ARNAS Garibaldi P O Nesima
Catania, 95122, Italy
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AZ Nikolaas - Campus Sint-Niklaas Moerland
Sint-Niklaas, 9100, Belgium
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Aarhus University Hospital
Aarhus, 8200, Denmark
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Akademiska Sjukhuset
Uppsala, 75185, Sweden
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Alexandra General Hospital of Athens
Athens, 115 28, Greece
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Ankara Universitesi Tip Fakultesi Cebeci Arastirma ve Uygulama Hastanesi
Ankara, 06620, Turkey (Türkiye)
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Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, T2N 5G2, Canada
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Asst Ovest Milanese - Ospedale Di Legnano
Legnano, 20025, Italy
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Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria
Alessandria, 15121, Italy
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Azienda Ospedaliera Universitaria Integrata Verona
Verona, 37134, Italy
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Beijing Chaoyang Hospital
Beijing, 100020, China
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Blackpool Victoria Hospital
Blackpool, FY3 8NR, United Kingdom
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Bon Secours Saint Francis Cancer Center
Greenville, South Carolina, 29607, United States
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Box Hill Hospital
Box Hill, 3128, Australia
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British Columbia Cancer Agency
Vancouver, British Columbia, V5Z4E6, Canada
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CHRU Tours Hopital Bretonneau
Tours, 37044, France
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CHU Nantes
Nantes, 44093, France
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CHU de Bordeaux - Hospital Haut-Leveque
Pessac, 33604, France
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CHU de Limoges Hopital Dupuytren
Limoges, 87042, France
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CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont
Montreal, Quebec, H1T 2M4, Canada
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Carmel Medical Center
Haifa, 3436212, Israel
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Catharinaziekenhuis
Eindhoven, 5623 EJ, Netherlands
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Centro de Quimioterapia e Investigacion
Guadalajara, 45645, Mexico
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Centrum Onkologii Ziemii Lubelskiej
Lublin, 20-090, Poland
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Cetus Oncologia
Belo Horizonte, 30110-022, Brazil
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Changzhou No 2 Peoples Hospital
Changzhou, 213000, China
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Chonnam National University Hwasun Hospital
Jeollanam-do, 58128, South Korea
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City of Hope Cancer Center
Newnan, Georgia, 30265, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Clinica Medica Sao Germano S/S LTDA
São Paulo, 04537-081, Brazil
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Clinica Univ. de Navarra
Pamplona, 31008, Spain
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Complejo Hosp de Navarra - Hosp de Navarra
Pamplona, 31008, Spain
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DF Star
Brasília, 70390-140, Brazil
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Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
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Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032, Hungary
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Deenanath Mangeshkar Hospital and Research Centre
Pune, 411004, India
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Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely
Budapest, 1097, Hungary
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Dong-A University Hospital
Busan, 49201, South Korea
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Duke University Medical Center
Durham, North Carolina, 27705, United States
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Fakultni Nemocnice Ostrava
Ostrava, 708 52, Czechia
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Fakultni nemocnice Brno
Brno-Bohunice, 625 00, Czechia
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Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05, Czechia
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First hospital affiliated of Zhejiang Medical university
Hangzhou, 310003, China
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Flevoziekenhuis
Almere Stad, 1315RA, Netherlands
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Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano
Milan, 20122, Italy
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Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
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Fortis Memorial Research Institute
Gurgaon, 122002, India
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Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109, United States
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Fujian Meidical University Union Hospital
Fuzhou, 350001, China
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Fukuoka University Hospital
Fukuoka, 814-0180, Japan
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Fundacao Antonio Prudente A C Camargo Cancer Center
São Paulo, 01509 900, Brazil
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Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
São José do Rio Preto, 15090 000, Brazil
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Fundacao Universidade de Caxias do Sul
Caxias do Sul, 95070 560, Brazil
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Fundaleu
Buenos Aires, C1114AAN, Argentina
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Gabrail Cancer Center
Canton, Ohio, 44718, United States
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Ghent University Hospital
Ghent, 9000, Belgium
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Gold Coast University Hospital
Southport, 4215, Australia
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Grand Hopital De Charleroi Site Les Viviers
Charleroi, 6060, Belgium
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Gundersen Health System
La Crosse, Wisconsin, 54601, United States
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Haga ziekenhuis
The Hague, 2545 CH, Netherlands
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Hamamatsu University Hospital
Hamamatsu, 431 3192, Japan
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Hematologica Alta Especialidad
Huixquilucan, 52787, Mexico
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Henry Ford Cancer Institute
Detroit, Michigan, 48202, United States
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Henry Ford Health Providence Southfield Hospital
Southfield, Michigan, 48075, United States
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Hopital Claude Huriez
Lille, 59000, France
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Hopital Saint Louis
Paris, 75010, France
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Hosp Clinico Univ de Salamanca
Salamanca, 37007, Spain
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Hosp Univ Vall D Hebron
Barcelona, 08035, Spain
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Hosp. Clinico Univ. de Santiago
Santiago de Compostela, 15706, Spain
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Hosp. San Pedro de Alcantara
Cáceres, 10003, Spain
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Hosp. Univ. Donostia
Donostia / San Sebastian, 20014, Spain
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Hosp. Univ. La Paz
Madrid, 28046, Spain
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Hosp. Univ. Lucus Augusti
Lugo, 27003, Spain
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Hosp. Univ. Marques de Valdecilla
Santander, 39008, Spain
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Hosp. Univ. Son Espases
Palma de Mallorca, 07120, Spain
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Hosp. Univ. Virgen de Las Nieves
Granada, 18014, Spain
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Hosp. Univ. de Burgos
Burgos, 09003, Spain
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Hosp. de Cabuenes
Asturias, 33394, Spain
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Hospices Civils de Lyon HCL
Lyon, 69002, France
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Hospital Aleman
CABA, C1118AAT, Argentina
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Hospital Britanico de Buenos Aires
Buenos Aires, C1280AEB, Argentina
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Hospital De Clinicas De Porto Alegre
Porto Alegre, 90035-903, Brazil
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Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer
Curitiba, 81520-060, Brazil
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Hospital Sao Rafael
Salvador, 41253 190, Brazil
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Hospital Universitario Dr Jose Eleuterio Gonzalez
Monterrey, 64460, Mexico
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Houston Methodist Neal Cancer Center at Texas Medical Center
Houston, Texas, 77030, United States
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Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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Hyogo Medical University Hospital
Nishinomiya Shi, 663 8501, Japan
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IRCCS Ospedale San Raffaele
Milan, 20132, Italy
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Institut Paoli Calmettes
Marseille, 13009, France
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Institut Universitaire du Cancer Toulouse Oncopole
Toulouse, 31100, France
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Institut de Cancerologie Strasbourg Europe ICANS
Strasbourg, 67200, France
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Instituto D Or de Pesquisa e Ensino
São Paulo, 04543 000, Brazil
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Instituto D Or de Pesquisa e Ensino IDOR
Recife, 50070-480, Brazil
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Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)
Rio de Janeiro, 22793-080, Brazil
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Isala Kliniek
Zwolle, 8025 AB, Netherlands
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Iwate Medical University Hospital
Shiwa-gun, 028-3695, Japan
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Japanese Red Cross Medical Center
Shibuya-ku, 150-8935, Japan
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Japanese Red Cross Narita Hospital
Narita, 286-8523, Japan
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Japanese Red Cross Osaka Hospital
Osaka, 543-8555, Japan
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John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Juntendo University Hospital
Bunkyō City, 113 8431, Japan
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Juravinski Cancer Centre
Hamilton, Ontario, L8V5C2, Canada
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Kanagawa Cancer Center
Yokohama, 241 8515, Japan
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Kanazawa University Hospital
Kanazawa, 920 8641, Japan
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King Abdullah International Medical Research Center (KAIMRC)
Riyadh, 11481, Saudi Arabia
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King Fahad Medical City
Riyadh, 12231, Saudi Arabia
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King Faisal Specialist Hospital & Research Center
Riyadh, 11564, Saudi Arabia
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Kings College Hospital
London, SE5 9RS, United Kingdom
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Klinik Ottakring
Vienna, 1160, Austria
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Klinikum Augsburg
Augsburg, 86156, Germany
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Klinikum rechts der Isar der TU Muenchen
München, 81675, Germany
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Kootenai Health
Coeur d'Alene, Idaho, 83814, United States
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LKH - Universitätsklinikum der PMU Salzburg
Salzburg, 05020, Austria
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Liv Hospital Ankara
Ankara, 06680, Turkey (Türkiye)
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Louis Stokes Cleveland VA Med Ctr
Cleveland, Ohio, 44106, United States
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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Luminis Health Center for Cancer and Blood Disorders
Annapolis, Maryland, 21401, United States
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Mayo Clinic Rochester
Rochester, Minnesota, 55905, United States
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Medical College Of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Medical Oncology Hematology Consultants, PA
Newark, Delaware, 19713, United States
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Medical University Vienna MUV
Vienna, A-1090, Austria
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Medical University of South Carolina
Charleston, South Carolina, 29425-8900, United States
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Medipol University Hospital
Istanbul, 34214, Turkey (Türkiye)
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Memorial Healthcare System
Hollywood, Florida, 33021, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Nanfang Hospital of Southern Medical Hospital
Guangzhou, 510515, China
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Nanjing Drum Tower Hospital
Nanjing, 210008, China
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National Hospital Organization Nagasaki Medical Center
Nagasaki, 856-8562, Japan
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Niigata Cancer Center Hospital
Niigata, 951-8566, Japan
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Ninewells Hospital
Dundee, DD1 9SY, United Kingdom
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Norrlands Universitetssjukhus
Umeå, 901 85, Sweden
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NorthWest Medical Specialties, PLLC
Tacoma, Washington, 98405, United States
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Norton Cancer Institute
Louisville, Kentucky, 40207, United States
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Nottingham City Hospital
Nottingham, NG5 1PB, United Kingdom
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Nova Scotia Health Authority
Halifax, Nova Scotia, B3H 1V7, Canada
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Odense University Hospital
Odense C, 5000, Denmark
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Oncologia Medica-Città Della Salute E Della Scienza Di Torino
Torino, 10126, Italy
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Ondokuz Mayis Universitesi Saglik Uygulama ve Arastirma Merkezi
Samsun, 55200, Turkey (Türkiye)
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Oregon Health And Science University
Portland, Oregon, 97239, United States
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Ospedale Policlinico San Martino IRCCS
Genova, 16132, Italy
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Ospedale S. Maria Delle Croci
Ravenna, 48121, Italy
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Our Lady of the Lake Hospital
Baton Rouge, Louisiana, 70808, United States
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Pamukkale Universitesi Tip Fakultesi
Denizli, 20070, Turkey (Türkiye)
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Pecsi Tudomanyegyetem Klinikai Kozpont
Pécs, 7624, Hungary
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Peking University First Hospital
Beijing, 100034, China
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Peking University People's Hospital
Beijing, 101199, China
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Peking University Shenzhen Hospital
Shenzhen, 518036, China
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Penn State Milton S Hershey Medical Ctr
Hershey, Pennsylvania, 17033, United States
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Perth Blood Institute
West Perth, 6005, Australia
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Presidio Ospedaliero Pescara
Pescara, 65124, Italy
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Princess Margaret Cancer Centre University Health Network
Toronto, Ontario, M5G2M9, Canada
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Pusan National University Hospital
Busan, 49241, South Korea
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Qilu Hospital of Shandong University
Jinan, 250012, China
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Queen Alexandra Hospital
Portsmouth, PO6 3LY, United Kingdom
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Rabin Medical center - Petah-Tikva
Petah Tikva, 49100, Israel
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Real e Benemerita Associacao Portuguesa de Beneficencia
São Paulo, 01323 001, Brazil
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Regions Hospital
Saint Paul, Minnesota, 55101, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Royal Adelaide Hospital
Adelaide, 5000, Australia
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Ruijing Hospital Affiliated To Shanghai Jiaotong University School Of Medicine
Shanghai, 200025, China
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SUNY Upstate Medical University
Syracuse, New York, 13210, United States
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Samsung Medical Center
Seoul, 06351, South Korea
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Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow, 226014, India
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Sapporo City General Hospital
Sapporo, 060-8604, Japan
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Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4, Canada
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Semmelweis Egyetem, Belgyogyaszati es Hematologiai Klinika
Budapest, 1088, Hungary
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Seoul National University Hospital
Seoul, 03080, South Korea
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Shamir Medical Center Assaf Harofeh
Be’er Ya‘aqov, 70300, Israel
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Shanghai Fourth People s Hospital
Shanghai, 200434, China
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Shanxi Bethune Hospital
Taiyuan, 030032, China
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Sheba Medical Center
Ramat Gan, 52621, Israel
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Shengjing Hospital Of China Medical University
Shenyang, 110055, China
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Shizuoka Cancer Center
Sunto Gun, 411 8777, Japan
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Sichuan Provincial Peoples Hospital
Chengdu, 610032, China
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Skanes universitetssjukhus
Lund, 221 85, Sweden
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St James University Hospital
Leeds, LS9 7TF, United Kingdom
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St Vincents Hospital
Darlinghurst, 2010, Australia
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St Vincents Hospital Melbourne
Fitzroy, 3065, Australia
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St. Antonius Ziekenhuis Nieuwegein
Nieuwegein, 3435 CM, Netherlands
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Sun Yat Sen University Cancer Center
Guangzhou, 510060, China
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Swedish Cancer Institute
Seattle, Washington, 98104, United States
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Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach
Kielce, 25 734, Poland
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Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz
Nyíregyháza, 4400, Hungary
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Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza
Brzozów, 36-200, Poland
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Tel Aviv Sourasky Medical Center
Tel Aviv, 64239, Israel
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The Affiliated Hospital of Inner Mongolia Medical College
Hohhot, 010051, China
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The Cancer Institute Hospital of JFCR
Tokyo, 135 8550, Japan
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The Catholic University of Korea Seoul St Mary s Hospital
Seoul, 06591, South Korea
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The First Affiliated Hospital of Fujian Medical University
Fuzhou, 350005, China
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The First Affiliated Hospital of Guangxi Medical University
Nanning, 530021, China
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The First Affiliated Hospital of NanChang University
Nanchang, 330006, China
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The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000, China
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The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, 710004, China
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The Second Affiliated Hospital of Zhejiang University College of Medicine
Hangzhou, 310009, China
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The Second Xiangya Hospital of Central South Hospital
Changsha, 410011, China
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The Sidney Kimmel Comprehensive Cancer Center at John Hopkins
Baltimore, Maryland, 21287, United States
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The University of Osaka Hospital
Suita, 565 0871, Japan
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The first affiliated hospital of xiamen university
Xiamen, 361026, China
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Theageneio Cancer Hospital
Thessaloniki, 546 39, Greece
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Thomas Jefferson University
Philadelphia, Pennsylvania, 19107 4215, United States
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Tianjin Medical University Cancer Institute and Hospital
Tianjin, 30060, China
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Tohoku University Hospital
Sendai, 980 8574, Japan
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Tongji Hospital of Tongji University
Shanghai, 200065, China
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Tongji Hospital, Tongji Medical College of HUST
Wuhan, 430030, China
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Tottori University Hospital
Tottori, 683-0824, Japan
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UCLA
Santa Monica, California, 90404, United States
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UCSF Fresno
Clovis, California, 93611, United States
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UT Southwestern
Dallas, Texas, 75390, United States
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UT Southwestern Parkland Hospital
Dallas, Texas, 75390, United States
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Ulsan University Hospital
Ulsan, 44033, South Korea
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Universitaetsklinikum Halle Saale
Halle, 06120, Germany
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Universitaetsklinikum Heidelberg
Heidelberg, 69120, Germany
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Universitaetsklinikum Magdeburg A.oe.R
Magdeburg, 39120, Germany
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Universitaetsklinikum Tuebingen
Tübingen, 72076, Germany
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Universitaetsklinikum Wuerzburg
Würzburg, 97080, Germany
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University Hospital Kyoto Prefectural University of Medicine
Kyoto, 602-8566, Japan
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University Hospital Olomouc
Olomouc, 779 00, Czechia
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University Hospital of Wales
Cardiff, CF14 4HY, United Kingdom
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University Hospitals Plymouth NHS Trust
Plymouth, PL6 8DH, United Kingdom
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University Of Minnesota
Minneapolis, Minnesota, 55455, United States
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University Of Pittsburgh Medical Center UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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University of Iowa Health Care
Waukee, Iowa, 50263, United States
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University of Maryland School of Medicine
Baltimore, Maryland, 21201, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Nebraska
Omaha, Nebraska, 68105, United States
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University of Tsukuba Hospital
Tsukuba, 305 8576, Japan
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University of Virginia
Charlottesville, Virginia, 22903, United States
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Uniwersytecki Szpital Kliniczny Nr 1 PUM im prof Tadeusza Sokolowskiego w Szczecinie
Szczecin, 71-252, Poland
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Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu
Wroclaw, 50 367, Poland
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Varberg Hospital
Varberg, 432 81, Sweden
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Vejle Hospital
Vejle, 7100, Denmark
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Weill Cornell Medical College
New York, New York, 10065, United States
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West Penn Hospital
Pittsburgh, Pennsylvania, 15224, United States
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Winship Cancer Institute Emory University
Atlanta, Georgia, 30322, United States
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Wojewodzki Szpital Specjalistyczny
Biała Podlaska, 21 500, Poland
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Wollongong Hospital
Wollongong, 2500, Australia
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Yale University School Of Medicine
New Haven, Connecticut, 06519, United States
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Ziekenhuis Oost-Limburg
Genk, 3600, Belgium
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oncologia medica - Oncology
Brindisi, 72100, Italy
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