Promising combo for tough blood cancers hits early snag

NCT ID NCT04809467

Terminated Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a combination of two targeted drugs, tafasitamab and parsaclisib, in 54 adults with relapsed or refractory non-Hodgkin lymphoma or chronic lymphocytic leukemia. The goal was to see if the combination was safe and could shrink tumors. However, the trial was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tafasitamab (a targeted antibody) and parsaclisib (a targeted pill)
What this could lead to: If successful, this combination could offer a new treatment option for people with blood cancers that have stopped responding to standard therapies.
What could go wrong: This was a very early (Phase 1b/2a) trial that was terminated early, so we don't know if the combination is safe or effective. Side effects from these drugs can be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia leukemia non-Hodgkin lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA NON-HODGKIN LYMPHOMA

Contacts and locations

Locations

AZ DELTA

Roeselare, 08800, Belgium
Az Groeninge Campus Kennedylaan

Kortrijk, 08500, Belgium
Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello

Palermo, 90146, Italy
Azienda Ospedaliero Universitaria Pisana

Pisa, 56126, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
Cancer Center For Blood Disorders

Bethesda, Maryland, 20817, United States
Centre Henri Becquerel

Rouen, 76038, France
Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hotel-Dieu

Nantes, 44093, France
Centro Integral Oncologico Clara Campal (Ciocc)

Madrid, 28050, Spain
Clinical Research Alliance

New Hyde Park, New York, 11042, United States
Community Health Network, Inc.

Indianapolis, Indiana, 46250, United States
Fondazione Irccs Istituto Nazionale Dei Tumori

Milan, 20133, Italy
Grand Hospital de Charleroi

Charleroi, 06000, Belgium
Hanusch-Krankenhaus Der Wiener Gebietskrankenkasse

Vienna, 01140, Austria
Hopital Sant Pau

Barcelona, 08036, Spain
Hospital Clinico Universitario de Salamanca

Salamanca, 37007, Spain
Hospital General Universitario Vall D Hebron

Barcelona, 08035, Spain
Hospital General Universitario de Valencia

Valencia, 46014, Spain
Hospital General Unviersitario de Alicante

Alicante, 03010, Spain
Hospital Puerta de Hierro

Majadahonda, 28222, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Central de Asturias

Oviedo, 33011, Spain
Hospital Universitario Marques de Valdecilla

Santander, 39008, Spain
Hospital Universitario Quironsalud Madrid

Madrid, 28223, Spain
Hospital Universitario San Cecilio

Granada, 18016, Spain
Hospital Universitario Virgen Del Rocio

Seville, 41015, Spain
Ico Institut Catala D Oncologia

Barcelona, 08908, Spain
Indiana Blood and Marrow Transplantation

Indianapolis, Indiana, 46237, United States
Institut Gustave Roussy

Villejuif, 94805, France
Institut Jules Bordet

Brussels, B-1070, Belgium
Irccs Istituto Clinico Humanitas

Rozzano, 20089, Italy
Istituto Nazionale Tumori Irccs Fondazione Pascale

Naples, 80131, Italy
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori

Meldola, 47014, Italy
Jefferson University Hospitals

Philadelphia, Pennsylvania, 19107, United States
Justus-Liebig University

Giessen, 35392, Germany
Landeskrankenhaus Salzburg

Salzburg, 05020, Austria
Norton Cancer Institute

Louisville, Kentucky, 40202, United States
Ohio State University

Columbus, Ohio, 43210, United States
Ordensklinikum Linz Gmbh Elisabethinen

Linz, A-4020, Austria
Ospedale Santa Maria Delle Croci

Ravenna, 48121, Italy
S Orsolas University Hospital Seragnoli Institute of Hematology

Bologna, 40138, Italy
Universitair Ziekenhuis (Uz) Leuven

Leuven, 03000, Belgium
Universitair Ziekenhuis Antwerpen (Uza)

Edegem, 02650, Belgium
Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii

Mainz, 55131, Germany
University Hospital Brest

Brest, 29609, France
University Hospital Wurzburg

Würzburg, 97080, Germany
University Medical Center Freiburg

Freiburg im Breisgau, 79106, Germany
University of Alabama At Birmingham Comprehensive Cancer Center

Birmingham, Alabama, 35205, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Southern California

Los Angeles, California, 90089, United States

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