Can a targeted cancer drug deliver in the real world?

NCT ID NCT06846996

NEW Recruiting now Disease control Sponsor: Daiichi Sankyo Source: ClinicalTrials.gov ↗

First seen Aug 18, 2026 · Last updated Aug 18, 2026

Summary

This observational study is tracking 260 adults in China with HER2-positive gastric or gastroesophageal junction cancer that is locally advanced or has spread. Participants are receiving trastuzumab deruxtecan (T-DXd) as part of their routine care, and researchers are collecting data on how long the treatment works before it stops being effective and what side effects occur. The goal is to see if the promising results from clinical trials hold up in everyday practice, especially for Chinese patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: trastuzumab deruxtecan (T-DXd), an antibody-drug conjugate that targets HER2-positive cancer cells
What this could lead to: If successful, this study could provide stronger evidence that T-DXd works well and is safe for Chinese patients with HER2-positive stomach cancer, potentially improving treatment guidelines and access.
What could go wrong: As an observational study, it does not compare T-DXd to other treatments, so results may be influenced by patient differences. Side effects, including serious ones, are still possible and will be monitored.

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Conditions

The condition(s) this trial relates to.

gastric cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HER2-POSITIVE GASTRIC CANCER HER2-POSITIVE GASTROESOPHAGEAL JUNCTION

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Affiliated Cancer Hospital and Institute of Guangzhou Medical University
RECRUITING

Guangzhou, 510095, China
Anhui Province Cancer Hoospital
RECRUITING

Hefei, 236000, China
Beijing Cancer Hospital
RECRUITING

Beijing, 100142, China
Beijing Chaoyang Hospital, Capital Medical University
RECRUITING

Beijing, 100020, China
Beijing Friendship Hospital,Capital Medical University
RECRUITING

Beijing, 100032, China
Beijing GoBroad Hospital
RECRUITING

Beijing, 102206, China
Cancer Hospital of Shantou University Medical College
RECRUITING

Shantou, 515000, China
Changzhi People's Hospital
RECRUITING

Changzhi, 046000, China
China-Japan Friendship Hospital
RECRUITING

Beijing, 100029, China
Chinese Academy of Medical Sciences Cancer Hospital
RECRUITING

Beijing, 100021, China
Fudan University Affiliated Cancer Hospital
RECRUITING

Shanghai, 200032, China
Fujian Cancer Hospital
RECRUITING

Fuzhou, 350000, China
Guangdong Hospital of Traditional Chinese Medicine
RECRUITING

Guangzhou, 510120, China
Guangdong Provincial People's Hospital
RECRUITING

Guangzhou, 510080, China
Hainan General Hospital
RECRUITING

Haikou, 570100, China
Henan Cancer Hospital
RECRUITING

Zhengzhou, 450008, China
Huadong Hospital Affiliated to Fudan University
RECRUITING

Shanghai, 201104, China
Jiangmen Central Hospital
RECRUITING

Jiangmen, 529000, China
Jiangsu Cancer Hospital
RECRUITING

Nanjing, 210009, China
Liaoning Cancer Hospital
WITHDRAWN

Shenyang, 110000, China
Nanjing Drum Tower Hospital
RECRUITING

Nanjing, 210000, China
Peking Union Medical College Hospital
WITHDRAWN

Beijing, 100032, China
Peking University First Hospital
RECRUITING

Beijing, 100034, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, 200025, China
Shanghai GoBroad Cancer Hospital
RECRUITING

Shanghai, 200003, China
Shanghai ninth People's Hospital,Shanghai Jiaotong University School of Medicine
NOT_YET_RECRUITING

Shanghai, 200011, China
Shanxi Cancer Hospital
RECRUITING

Taiyuan, 030000, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
WITHDRAWN

Hangzhou, 310009, China
Taizhou Hospital of Zhejiang Province
RECRUITING

Taizhou, 317700, China
The Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, 710061, China
The Affiliated Hospital of Xiamen University
RECRUITING

Xiamen, 361003, China
The Affiliated Hospital of Xuzhou Medical University
RECRUITING

Xuzhou, 221006, China
The First Affiliated Hospital of Zhengzhou University
WITHDRAWN

Zhengzhou, 450066, China
The First Affiliated Hospital, Sun Yat-sen University
RECRUITING

Guangzhou, 510080, China
The First Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, 130031, China
The Second Affiliated Hospital Zhejiang University School of Medicine
RECRUITING

Hangzhou, 310009, China
The Second Hospital of Tianjin Medical University
RECRUITING

Tianjin, 300211, China
Tianjin Medical University Cancer Institute and Hospital
RECRUITING

Tianjin, 300000, China
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, 310005, China
Zhongshan Hospital
RECRUITING

Shanghai, 200032, China

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