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New CAR T-Cell therapy SynKIR-310 enters first human trial for Tough-to-Treat lymphoma

NCT ID NCT06544265

Recruiting now Disease control Sponsor: Verismo Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new treatment called SynKIR-310 for adults with B-cell non-Hodgkin lymphoma that has come back or not responded to at least two prior therapies. The treatment uses a patient's own immune cells, modified to target and attack cancer cells. The main goals are to check safety and find the right dose, while also looking at how well it works.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

aggressive B-cell non-Hodgkin lymphoma B-cell neoplasm B-cell non-Hodgkin lymphoma diffuse large B-cell lymphoma follicular lymphoma high grade B-cell lymphoma hypertrophic pyloric stenosis indolent B-cell non-Hodgkin lymphoma interdigitating dendritic cell sarcoma large B-cell lymphoma Lymphoma, B-Cell, Marginal Zone mantle cell lymphoma marginal zone lymphoma non-Hodgkin lymphoma primary mediastinal large B-cell lymphoma splenic marginal zone lymphoma T-cell/histiocyte rich large B cell lymphoma Waldenstrom macroglobulinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMA B-CELL LYMPHOMA DIFFUSE LARGE B-CELL LYMPHOMA DLBCL DLBCL (DIFFUSE LARGE B-CELL LYMPHOMA) ASSOCIATED WITH CHRONIC INFLAMMATION DLBCL - DIFFUSE LARGE B CELL LYMPHOMA EPSTEIN-BARR VIRUS POSITIVE DLBCL, NOS FOLLICULAR LYMPHOMA FOLLICULAR LYMPHOMA GRADE 3 FOLLICULAR LYMPHOMA GRADE 3B HGBL WITH MYC AND BCL2 AND/OR BCL6 REARRANGEMENTS HIGH GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED HIGH-GRADE B-CELL LYMPHOMA INDOLENT B-CELL NON-HODGKIN LYMPHOMA LARGE B-CELL LYMPHOMA MANTLE CELL LYMPHOMA MARGINAL ZONE LYMPHOMA MARGINAL ZONE SPLENIC LYMPHOMA NHL, ADULT NON-HODGKIN LYMPHOMA,B CELL PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA (PMBCL) REFRACTORY NON-HODGKIN LYMPHOMA RELAPSED NON-HODGKIN LYMPHOMA T-CELL/HISTIOCYTE RICH LYMPHOMA WALDENSTROM MACROGLOBULINAEMIA WALDENSTROM MACROGLOBULINEMIA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Abramson Cancer Center of the University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Colorado Blood Cancer Institute, part of Sarah Cannon Cancer Institute

    RECRUITING

    Denver, Colorado, 80218, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Rutgers Cancer Institute

    RECRUITING

    New Brunswick, New Jersey, 08902, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • The University of Kansas Cancer Center

    RECRUITING

    Fairway, Kansas, 66205, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Winship Cancer Institute of Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••