New trial aims to halve deaths in newborns with severe heart disease

NCT ID NCT07363538

Recruiting now Disease control Sponsor: Central China Fuwai Hospital of Zhengzhou University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares performing heart surgery on newborns with complex congenital heart disease either before or after 7 days of age. Researchers will track which timing leads to fewer deaths and better recovery. The trial involves 738 babies across multiple hospitals in China.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgical operation
What this could lead to: If successful, this could establish the best timing for life-saving heart surgery in newborns, potentially halving death and non-recovery rates.
What could go wrong: This is a large trial but still early in its evaluation. The optimal timing may vary by individual, and results may not apply to all hospitals or countries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aorta coarctation congenital heart disease congenital total pulmonary venous return anomaly conotruncal heart malformations pulmonary atresia-intact ventricular septum syndrome pulmonic stenosis transposition of the great arteries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMPLEX CONGENITAL HEART DISEASE

Contacts and locations

Locations

Central China Fuwai Hospital of Zhengzhou University
RECRUITING

Zhengzhou, Henan, 450000, China
Children's Hospital Affiliated to Nanjing Medical University
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210008, China
Children's Hospital Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, China
Children's Hospital of Chongqing Medical University
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, China
Fuwai Hospital, Chinese Academy of Medical Sciences
RECRUITING

Beijing, Beijing Municipality, 100037, China
Guangzhou Women and Children's Medical Center, Guangzhou Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, China
Qingdao Women and Children's Hospital
NOT_YET_RECRUITING

Qingdao, Shandong, 266000, China
Shanghai Children's Medical Center (SCMC) Affiliated to Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, China
The First Affiliated Hospital of Air Force Medical University (Xijing Hospital)
NOT_YET_RECRUITING

Xi’an, Shanxi, China
The Second Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, Hunan, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, Hubei, China
West China Second Hospital of Sichuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, China

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