Can a gene test tell who will benefit from immunotherapy?

NCT ID NCT04953104

First seen Nov 01, 2025 · Last updated May 08, 2026 · Updated 28 times

Summary

This study looks at whether certain genetic changes in tumors can help predict how well the immunotherapy drug nivolumab works for people with advanced bladder cancer that has spread. Researchers are focusing on two genes, ARID1A and KDM6A, and a protein called CXCL13. The goal is to find better ways to choose which patients are most likely to benefit from this treatment.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.

LOCALLY ADVANCED BLADDER UROTHELIAL CARCINOMA LOCALLY ADVANCED RENAL PELVIS UROTHELIAL CARCINOMA LOCALLY ADVANCED URETER UROTHELIAL CARCINOMA LOCALLY ADVANCED URETHRAL UROTHELIAL CARCINOMA LOCALLY ADVANCED UROTHELIAL CARCINOMA METASTATIC BLADDER UROTHELIAL CARCINOMA METASTATIC RENAL PELVIS UROTHELIAL CARCINOMA METASTATIC URETER UROTHELIAL CARCINOMA METASTATIC URETHRAL UROTHELIAL CARCINOMA METASTATIC UROTHELIAL CARCINOMA RECURRENT BLADDER UROTHELIAL CARCINOMA RECURRENT RENAL PELVIS UROTHELIAL CARCINOMA RECURRENT URETER UROTHELIAL CARCINOMA RECURRENT URETHRAL UROTHELIAL CARCINOMA RECURRENT UROTHELIAL CARCINOMA STAGE III BLADDER CANCER AJCC V8 STAGE III BLADDER CANCER AJCC V8 STAGE III RENAL PELVIS CANCER AJCC V8 STAGE III RENAL PELVIS CANCER AJCC V8 STAGE III URETER CANCER AJCC V8 STAGE III URETER CANCER AJCC V8 STAGE III URETHRAL CANCER AJCC V8 STAGE III URETHRAL CANCER AJCC V8 STAGE IIIA BLADDER CANCER AJCC V8 STAGE IIIA BLADDER CANCER AJCC V8 STAGE IIIA BLADDER CANCER AJCC V8 STAGE IIIB BLADDER CANCER AJCC V8 STAGE IIIB BLADDER CANCER AJCC V8 STAGE IIIB BLADDER CANCER AJCC V8 STAGE IV BLADDER CANCER AJCC V8 STAGE IV RENAL PELVIS CANCER AJCC V8 STAGE IV RENAL PELVIS CANCER AJCC V8 STAGE IV URETER CANCER AJCC V8 STAGE IV URETER CANCER AJCC V8 STAGE IV URETHRAL CANCER AJCC V8 STAGE IV URETHRAL CANCER AJCC V8 STAGE IVA BLADDER CANCER AJCC V8 STAGE IVA BLADDER CANCER AJCC V8 STAGE IVB BLADDER CANCER AJCC V8 STAGE IVB BLADDER CANCER AJCC V8 UNRESECTABLE BLADDER UROTHELIAL CARCINOMA UNRESECTABLE RENAL PELVIS UROTHELIAL CARCINOMA UNRESECTABLE URETER UROTHELIAL CARCINOMA UNRESECTABLE URETHRAL UROTHELIAL CARCINOMA UNRESECTABLE UROTHELIAL CARCINOMA