Can an arthritis drug tame deadly COVID inflammation?

NCT ID NCT05822583

Completed Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

Summary

This trial tested if adding a drug called abatacept to standard hospital care could help people with moderate COVID-19 pneumonia. The goal was to see if calming an overactive immune response early could speed up recovery and prevent patients from getting sicker. The study involved 285 hospitalized adults who were on low levels of supplemental oxygen.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

1st Respiratory Medicine Department, Athens University Medical School (635-015)

Athens, Attica, 11527, Greece
3rd Dept of Medicine, Medical School, NKUA (635-022)

Athens, Attica, 11527, Greece
AIDS and Clinical Immunology Research Center (627-201)

Tbilisi, 0159, Georgia
Aalborg Hospital (Site 625-005)

Aalborg, 9000, Denmark
Aarhus Universitetshospital, Skejby (Site 625-002)

Aarhus, 8200, Denmark
Asan Medical Center (612-901)

Seoul, 05505, South Korea
Attikon University General Hospital (Site 635-009)

Athens, Attica, 12462, Greece
Austin Health (612-020)

Heidelberg, Victoria, 3084, Australia
Banner University Medical Center Tucson (Site 206-004)

Tucson, Arizona, 85719, United States
Baylor, Scott and White Health (301-003)

Dallas, Texas, 75246, United States
Baystate Medical Center (Site 201-001)

Springfield, Massachusetts, 01199, United States
Beth Israel Deaconess Medical Center (202-001)

Boston, Massachusetts, 02215, United States
Bispebjerg Hospital (Site 625-013)

Copenhagen, 2400, Denmark
CHRISTUS Spohn Shoreline Hospital (080-001)

Corpus Christi, Texas, 78404, United States
Cedars-Sinai Medical Center (208-002)

Los Angeles, California, 90048, United States
Central City Clinical Hospital of Ivano-Frankivsk City Council (627-302)

Ivano-Frankivsk, 76018, Ukraine
Chennai Antiviral Research and Treatment Clinical Research Site (Site 612-402)

Chennai, Tamil Nadu, 600113, India
Chulalongkorn University and The HIV-NAT (Site 613-001)

Bangkok, 10330, Thailand
Chung-Ang University Hospital (612-902)

Seoul, 06973, South Korea
Cleveland Clinic Foundation (Site 207-001)

Cleveland, Ohio, 44195, United States
Cooper University Hospital (019-001)

Camden, New Jersey, 08103, United States
Dartmouth-Hitchcock Medical Center (301-024)

Lebanon, New Hampshire, 03756, United States
Democritus University of Thrace (635-021)

Alexandroupoli, Evros, 68131, Greece
Duke University Hospital (Site 301-006)

Durham, North Carolina, 27710, United States
Emory Grady (Site 301-032)

Atlanta, Georgia, 30303, United States
Froedtert Memorial Lutheran Hospital (052-001)

Milwaukee, Wisconsin, 53226, United States
Harborview Medical Center (208-001)

Seattle, Washington, 98104, United States
Hendrick Medical Center (Site 080-014)

Abilene, Texas, 79602, United States
Henry Ford Health System (014-001)

Detroit, Michigan, 48202, United States
Herlev/Gentofte Hospital (Site 625-012

Hellerup, 2900, Denmark
Hope Clinic, Emory University (Site 301-031)

Decatur, Georgia, 30030, United States
Hospital #1 of Zhytomyr City Council (627-303)

Zhytomyr, 10002, Ukraine
Hospital Clinic de Barcelona (626-004)

Barcelona, 08036, Spain
Hospital Universitari Germans Trias i Pujol (626-003)

Badalona, Barcelona, 08916, Spain
Hospital Universitari Vall d'Hebron (626-033)

Barcelona, 08035, Spain
Hospital Universitario La Paz (Site 626-012)

Madrid, 28046, Spain
Hospital del Mar (626-025)

Barcelona, 08003, Spain
Houston Methodist Research Institute (Site 301-028)

Houston, Texas, 77030, United States
Hvidovre University Hospital, Department of Infectious Diseases (Site 625-001)

Hvidovre, 2650, Denmark
Hôpital Saint André (Site 631-041)

Bordeaux, 33000, France
Institute of Human Virology-Nigeria (IHVN) (612-601)

Abuja, Federal Capital Territory, Nigeria
Intermountain Medical Center (Site 211-001)

Murray, Utah, 84107, United States
James J. Peters VAMC (Site 023-003)

The Bronx, New York, 10468, United States
Karolinska University Hospital, Solna (Site 625-206)

Stockholm, 171 76, Sweden
Khon Kaen University, Srinagarind Hospital (613-003)

Khon Kaen, 40002, Thailand
Klinik I für Innere Medizin der Universität zu Köln (622-008)

Cologne, 50937, Germany
Lahey Hospital and Medical Center (Site 213-001)

Burlington, Massachusetts, 01805, United States
Lincoln Medical Center (Site 003-016)

The Bronx, New York, 10451, United States
Lutheran Medical Group (301-010)

Fort Wayne, Indiana, 46804, United States
M Health Fairview University of Minnesota Medical Center (112-001)

Minneapolis, Minnesota, 55455, United States
Massachusetts General Hospital (202-002)

Boston, Massachusetts, 02114, United States
MedStar Health Research Institute (Site 009-021)

Washington D.C., District of Columbia, 20010, United States
Medical University of South Carolina (Site 210-002)

Charleston, South Carolina, 29425, United States
MemorialCare Health System (066-003)

Long Beach, California, 90806, United States
Monash Health (612-009)

Clayton, Victoria, 3168, Australia
Mount Sinai Medical Center (Site 301-012)

New York, New York, 11234, United States
NYC Health + Hospital Harlem (Site 003-003)

New York, New York, 10037, United States
NYU Brooklyn (301-033)

Brooklyn, New York, 11220, United States
NYU Long Island (301-034)

Mineola, New York, 11501, United States
National Medical Center (612-905)

Seoul, 04564, South Korea
New Jersey Medical School Clinical Research Center (028-001)

Newark, New Jersey, 07103, United States
New York Presbyterian Queens (003-005)

Flushing, New York, 11355, United States
New York University Langone Health (301-013)

New York, New York, 10016, United States
Nordsjællands Hospital, Hillerød (Site 625-009)

Hillerød, 3400, Denmark
Odense University Hospital (625-004)

Odense, C, 5000, Denmark
Oregon Health and Science University (208-003)

Portland, Oregon, 97239, United States
Parkland Health and Hospital Systems (084-002)

Dallas, Texas, 75235, United States
Penn State Health Milton S. Hershey Medical Center (Site 209-002)

Hershey, Pennsylvania, 17033, United States
Providence (Sacred Heart) (213-004)

Spokane, Washington, 99204, United States
Public Health Institute at Denver Health (Site 017-004)

Denver, Colorado, 80204, United States
Ralph H. Johnson VA Medical Center (074-015)

Charleston, South Carolina, 29401, United States
Rhode Island Hospital (Site 080-036)

Providence, Rhode Island, 02903, United States
Rigshospitalet, CHIP (Site 625-006)

Copenhagen, 2100, Denmark
Rocky Mountain Regional VA Medical Center (Site 074-010)

Aurora, Colorado, 80045, United States
Ronald Reagan UCLA Medical Center (Site 203-002)

Los Angeles, California, 90095, United States
Royal Brisbane and Women's Hospital (612-055)

Brisbane, Queensland, 4029, Australia
Salem VA Medical Center (Site 074-014)

Salem, Virginia, 24153, United States
San Francisco VAMC (Site 074-002)

San Francisco, California, 94121, United States
Seoul National University Bundang Hospital (612-904)

Seongnam, 13620, South Korea
Seoul St. Mary's Hospital (Site 612-903)

Seoul, 06591, South Korea
Sinai-Grace Hospital (Site 205-005)

Detroit, Michigan, 48235, United States
Siriraj Hospital (613-002)

Bangkok Noi, Bangkok, 10700, Thailand
Southern Arizona VA Healthcare System (Site 074-009)

Tucson, Arizona, 85723, United States
St Vincent's University Hospital (Site 634-103)

Dublin, D04 T6F4, Ireland
St. Vincent's Hospital (Site 612-002)

Sydney, New South Wales, 2010, Australia
Stanford University Hospital & Clinics (Site 203-003)

Stanford, California, 94305, United States
Tampa General Hospital (032-001)

Tampa, Florida, 33606, United States
Tan Tock Seng Hospital (Site 612-201)

Singapore, 308433, Singapore
The Alfred Hospital (612-017)

Melbourne, Victoria, 3004, Australia
The Miriam Hospital (Site 080-039)

Providence, Rhode Island, 02906, United States
Treatment and Diagnostic Center ADONIS Plus (627-304)

Kyiv, 02002, Ukraine
UC Davis Health (Site 203-004)

Davis, California, 95616, United States
UCSF Fresno (Site 203-005)

Fresno, California, 93721, United States
UCSF Medical Center (Site 203-001)

San Francisco, California, 94143, United States
UCSF Medical Center at Mount Zion (203-007)

San Francisco, California, 94115, United States
UT Health San Antonio (Site 009-022)

San Antonio, Texas, 78229, United States
UT Southwestern Medical Center (084-001)

Dallas, Texas, 75390, United States
University Hospital Basel (636-004)

Basel, 4031, Switzerland
University Hospital Plymouth NHS Trust (Site 634-014)

Plymouth, Devon, PL6 8DH, United Kingdom
University of Alabama Birmingham University Hospital (Site 213-002)

Birmingham, Alabama, 35233, United States
University of Colorado Hospital (Site 204-001)

Aurora, Colorado, 80045, United States
University of Illinois at Chicago (008-012)

Chicago, Illinois, 60612, United States
University of Kansas Medical Center (Site 080-044)

Kansas City, Kansas, 66160, United States
University of Massachusetts Chan Medical School (080-007)

Worcester, Massachusetts, 01655, United States
University of Michigan Medical Center (205-001)

Ann Arbor, Michigan, 48109, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Mississippi Medical Center (Site 202-005)

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center (Site 080-045)

Omaha, Nebraska, 68198, United States
University of New Mexico Hospital (Site 213-008)

Albuquerque, New Mexico, 87106, United States
University of Texas Health Science Center (Site 203-006)

Houston, Texas, 77030, United States
University of Utah Hospital (211-002)

Salt Lake City, Utah, 84108, United States
VA Ann Arbor Healthcare System (Site 074-028)

Ann Arbor, Michigan, 48105, United States
VA Loma Linda Healthcare System (074-017)

Loma Linda, California, 92357, United States
VA Long Beach Healthcare System (074-026)

Long Beach, California, 90822, United States
VA Northern California Health Care System (Site 074-023)

Mather, California, 95655, United States
VA San Diego Healthcare System (074-016)

San Diego, California, 92161, United States
Vanderbilt University Medical Center (Site 212-001)

Nashville, Tennessee, 37232, United States
Wake Forest Baptist Health (Site 210-001)

Winston-Salem, North Carolina, 27157, United States
Washington DC VA Medical Center (Site 009-004)

Washington D.C., District of Columbia, 20422, United States
Washington University School of Medicine (Site 003-001)

St Louis, Missouri, 63310, United States
Weill Cornell Clinical Research Unit (065-001)

New York, New York, 10065, United States
West Virginia University Medicine (Site 301-023)

Morgantown, West Virginia, 26506, United States
Westmead Hospital (Site 612-058)

Westmead, New South Wales, 2145, Australia
William S. Middleton Memorial Veterans Hospital (074-030)

Madison, Wisconsin, 53705, United States
Wojewodzki Szpital Zakazny (Site 625-302)

Warsaw, 01-201, Poland
Yale University (Site 025-001)

New Haven, Connecticut, 06510, United States
Zuckerberg San Francisco General Hospital and Trauma Center (213-007)

San Francisco, California, 94110, United States

Conditions

Explore the condition pages connected to this study.

COVID-19