Could adding chemo to precision radiation boost survival in head and neck cancer?
NCT ID NCT03070366
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This phase 2 trial compares stereotactic radiotherapy alone versus radiotherapy plus chemotherapy for people with head and neck cancer that has spread to 1-3 other spots in the body. The main goal is to see if the combination helps patients live at least one year without a drop in quality of life. About 78 adults with good performance status are being studied, and researchers are also looking at side effects and cost-effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Chemotherapy (cisplatin, 5FU, carboplatin, or cetuximab) plus stereotactic radiotherapy
- What this could lead to
- If successful, this could show that adding chemotherapy to targeted radiation helps people with head and neck cancer that has spread to a few spots live longer with better quality of life.
- What could go wrong
- This is a mid-stage trial with only 78 participants, so results may not apply to everyone. Chemotherapy can cause significant side effects, and the benefit over radiation alone is not yet proven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Nord Franche Comté
Montbéliard, 25209, France
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