New strategy aims to stop rapid bone loss after stopping osteoporosis drug

NCT ID NCT07281586

First seen Jan 04, 2026 · Last updated May 14, 2026 · Updated 25 times

Summary

This study tests whether a step-down approach—using half-dose denosumab (Prolia) combined with zoledronic acid (Aclasta)—can better prevent bone loss in people who have been on denosumab for at least three years. The trial includes 44 postmenopausal women and men aged 50–85 with osteoporosis or related fractures. The goal is to find a safer way to stop treatment without losing bone density.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Taiwan University Hospital Yunlin Branch

    RECRUITING

    Douliu, Taiwan, 640, Taiwan

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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