Stem cell transplant study halted early: which prep works best?
NCT ID NCT01366612
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two different drug combinations given before a stem cell transplant for people with myeloid blood cancers like leukemia. One group got fludarabine and busulfan, the other got those drugs plus low-dose total body irradiation. The goal was to see which regimen led to fewer cancer relapses within a year. The trial was stopped early after enrolling 53 adults, so the findings are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fludarabine and Busulfan, with or without low-dose total body irradiation
- What this could lead to
- If successful, this could help identify the best way to prepare patients for stem cell transplants, potentially reducing cancer relapse.
- What could go wrong
- The trial was terminated early with only 53 of 80 planned participants, so results are limited. Conditioning regimens carry serious risks like infection and organ damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ACUTE MYELOGENOUS LEUKEMIA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can trained immune cells stop blood cancer relapse?
- Can a modified enzyme starve Hard-to-Treat blood cancers?
- Can a Low-Dose antifungal shield vulnerable patients from deadly fungal infections?
- Can donor immune cells tame stem cell transplant risks?
- Can a poison become a cure? arsenic trioxide put to the test in blood cancer transplant
- Can a gentler chemo-radiation combo make stem cell transplants safer for blood cancers?