Cord blood stem cells aim to tame transplant complication
NCT ID NCT03158896
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage study tested whether stem cells from donated umbilical cords are safe for people with a serious condition called acute graft versus host disease (aGVHD), which can happen after a bone marrow transplant. Twenty-four adults received one of two doses of these stem cells. The main goal was to see if the treatment caused serious side effects, and researchers also looked for signs that it helped control the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
umbilical cord stem cells (Wharton's jelly mesenchymal stem cells)
What this could lead to
If this works, it could point toward a new treatment option for a serious complication of bone marrow transplants, helping control the immune attack on the body.
What could go wrong
This is a very early, small phase 1 trial with only 24 people, so it is mainly checking safety, not effectiveness. The stem cells may not work, and there are risks of side effects from the infusion.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Kansas University Cancer Center
Kansas City, Kansas, 66160, United States