New breathing device may help CF patients produce mucus for testing

NCT ID NCT06311292

Completed Knowledge-focused Sponsor: Daniel J. Weiner Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small pilot study tested whether a breathing device called the Volara System could help adults with cystic fibrosis produce sputum (mucus from the lungs) for lab testing. The study included 20 people who had not been able to produce a sputum sample in the past year. Participants used the device during a clinic visit to try to loosen and collect mucus. The goal was to see if this method could provide enough sputum for a successful culture result.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Volara System (a breathing device that delivers gentle air pulses to loosen mucus)
What this could lead to: If successful, this method could give doctors a better way to collect sputum for infection testing in people with cystic fibrosis who struggle to cough up mucus.
What could go wrong: This is a very small pilot study (20 people) with no comparison group, so results may not apply to everyone. The device may not work for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTIC FIBROSIS

Contacts and locations

Locations

UPMC Presbyterian Hospital

Pittsburgh, Pennsylvania, 15213, United States

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