Hope for rare skin disease: new drug shows promise in trial
NCT ID NCT05856526
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a medicine called spesolimab for people with Netherton syndrome, a rare genetic skin condition causing severe redness and scaling. About 43 people aged 12 and older took part, receiving either the drug or a placebo. The goal was to see if spesolimab could reduce skin symptoms over 4 months, with all participants eventually receiving the drug. The trial was stopped early, but results may still offer insights for future treatments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ASMC-IPSMC-skin and Veneral Diseases
Sofia, 1407, Bulgaria
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Azienda Ospedaliera Universitaria Citta Della Salute E Della Scienza Di Torino
Torino, 10126, Italy
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Beijing Children's Hospital, Capital Medical University
Beijing, 100045, China
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Dermatology Hospital, Chinese Academy of Medical Sciences
Nanjing, 210000, China
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Erasmus MC Sophia Kinderziekenhuis
Rotterdam, 3015 GD, Netherlands
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HOP Saint-Louis
Paris, 75010, France
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Hospital Tunku Azizah
Kuala Lumpur, 50300, Malaysia
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Istituto Dermopatico Dell'Immacolata - IDI - IRCCS
Roma, 00167, Italy
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Juntendo University Urayasu Hospital
Chiba, Urayasu, 279-0021, Japan
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Klinikum der Universität München AÖR
München, 80337, Germany
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Mission Dermatology Center
Rancho Santa Margarita, California, 92688, United States
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Nagoya University Hospital
Aichi, Nagoya, 466-8560, Japan
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Okayama University Hospital
Okayama, Okayama, 700-8558, Japan
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Queen Elizabeth University Hospital
Glasgow, G51 4TF, United Kingdom
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Shanghai Skin Disease Hospital
Shanghai, 200000, China
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Sourasky Medical Center
Tel Aviv, 6423906, Israel
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Southern Medical University Dermatology Hospital
Guangzhou, 510091, China
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The Children's Hospital Zhejiang University School Of Medicine
Hangzhou, 310000, China
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The First Affiliated Hospital, Zhejiang University
Hangzhou, 310003, China
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ULS de São José, E.P.E. - Hospital Sto. António Capuchos
Lisbon, 1169-050, Portugal
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University Children Hospital Zürich
Zurich, 8032, Switzerland
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Universitätsklinikum Heidelberg
Heidelberg, 69120, Germany
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Universitätsklinikum Schleswig-Holstein, Campus Kiel
Kiel, 24105, Germany
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Virginia Clinical Research, Inc.
Norfolk, Virginia, 23502, United States
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Westmead Hospital
Westmead, New South Wales, 2145, Australia
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Xinhua Hospital Affiliated to Shanghai Jiaotong University
Shanghai, 200092, China
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Yale University School of Medicine
New Haven, Connecticut, 06519, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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