Researchers launch study to understand rare paralysis conditions

NCT ID NCT06553976

Recruiting now Knowledge-focused Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is collecting health data and blood samples from 100 people with specific types of hereditary spastic paraplegia (SPG4 and SPG5A). The goal is to create a shared database and biobank to better understand how the disease progresses. This information will help prepare for future clinical trials and improve care for patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could provide the foundation for future clinical trials and better diagnostic tools for hereditary spastic paraplegia.
What could go wrong: This is an observational pilot study with only 100 participants, so it may not capture the full range of the disease. It does not test any treatment directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for EARLY ONSET HEREDITARY SPASTIC PARAPLEGIA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

hereditary spastic paraplegia hereditary spastic paraplegia 4 hereditary spastic paraplegia 5A lateral sclerosis motor neuron disorder neuromuscular disease Spastic Paraplegia Type 4

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY ONSET HEREDITARY SPASTIC PARAPLEGIA HEREDITARY SPASTIC PARAPLEGIA NEUROMUSCULAR DISEASES PRIMARY LATERAL SCLEROSIS SPASTIC PARAPLEGIA 4 SPASTIC PARAPLEGIA 5A SPASTIC PARAPLEGIA, HEREDITARY SPG4 SPG5A

Contacts and locations

Locations

Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02215, United States
Cincinnati Children's Hospital Medical Center
NOT_YET_RECRUITING

Cincinnati, Ohio, 45229-3039, United States
Columbia University - Irving Medical Center
NOT_YET_RECRUITING

New York, New York, 10032, United States
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02215, United States
Scottish Rite for Children
NOT_YET_RECRUITING

Dallas, Texas, 75219, United States
Seattle Children's Hospital
NOT_YET_RECRUITING

Seattle, Washington, 98105, United States
Texas Children's Hospital
NOT_YET_RECRUITING

Houston, Texas, 77035, United States
University of Iowa Carver College of Medicine
NOT_YET_RECRUITING

Iowa City, Iowa, 52242, United States
University of Miami Miller School of Medicine
NOT_YET_RECRUITING

Miami, Florida, 33136, United States
University of Michigan School of Medicine
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Washington School of Medicine
NOT_YET_RECRUITING

Seattle, Washington, 98195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.