New combo tackles Hard-to-Treat myeloma

NCT ID NCT01562405

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 28 times

Summary

This early-stage study tests a new drug, sotatercept, combined with two standard treatments (lenalidomide or pomalidomide plus dexamethasone) in 33 adults with multiple myeloma that has returned or not responded to prior therapy. The main goal is to find the safest dose of sotatercept and begin to see if the combination can shrink tumors and improve anemia and bone damage.

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Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02215, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Massachusetts General Hosptial

    Boston, Massachusetts, 02115, United States

Conditions

Explore the condition pages connected to this study.