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Can writing and performing your own song quiet the voices of schizophrenia?

NCT ID NCT05929352

Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study tests whether making music in a group can help people with schizophrenia who hear voices. Participants will be randomly assigned to one of four activities: creating and performing their own song, singing karaoke, listening to popular music, or curating playlists. The goal is to see if actively creating music changes how the brain processes sounds and social cues, potentially reducing hallucinations.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Musical intervention: group song-making sessions led by a trained musician
What this could lead to
If effective, group song-making could become a new supportive therapy to reduce hallucinations and improve social functioning in people with schizophrenia.
What could go wrong
This is an early-stage trial with a modest number of participants, so results may not be conclusive. The intervention is not a cure and may only provide temporary relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

135 people

The number who actually took part.

Started

Oct 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * voice hearing patients meeting diagnostic criteria for Diagnostic and Statistical Manual-V psychotic disorder * hearing voices at least once a day * PANSS P3 (Hallucinations item) greater than 3 * Prior to study participation all patients will be evaluated for i) protocol eligibility; ii) ability to give informed consent; iii) interaction with the study team to determine participant's probability of completing the study; and iv) ability to cooperate with protocol procedures. The flow of all participants will be reviewed at weekly research meetings in consultation with the study team. Exclusion Criteria: * Diagnostic and Statistical Manual-IV substance abuse or dependence (past six months) * clinically significant medical conditions, head injury with neurological symptoms or unconsciousness * mental retardation (IQ\<70) * Non-English speaking * no less than 2 weeks of stable doses of psychotropic medications (to avoid transient effects of medication regiment change; medication type and dose will be carefully recorded and used as a covariate in all analyses) * Co-morbid mood or anxiety diagnosis * clinically/behaviorally unstable and unable to cooperate with SING procedures * Unstable medical condition based on medical history, physical examination and routine laboratory work-up

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Conditions

The condition(s) this trial relates to.

Hallucinations schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Schizophrenia

Contacts and locations

Locations

  • Department of Psychiatry, Yale School of Medicine

    New Haven, Connecticut, 06519, United States

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